Sodium metatungstate hydrate

Name: Sodium metatungstate hydrate
Brand: TargetMol
SKU: T208708
Rating: 4.5 (1 reviews)

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Catalog No. T208708Cas No. 314075-43-9

Alias Sodium polyoxotungstate hydrate, POM-1 hydrate

Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is an inhibitor of NTPDase, with Ki values for NTPDase1 (CD39), NTPDase 3, and NTPDase 2 being 2.58 μM, 3.26 μM, and 28.8 μM, respectively. It exhibits anti-inflammatory and anticancer properties and inhibits ATP hydrolysis while also blocking central synaptic transmission.

Sodium metatungstate hydrate

🥰Excellent

Catalog No. T208708Alias Sodium polyoxotungstate hydrate, POM-1 hydrateCas No. 314075-43-9

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Product Introduction

Bioactivity

Description	Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is an inhibitor of NTPDase, with Ki values for NTPDase1 (CD39), NTPDase 3, and NTPDase 2 being 2.58 μM, 3.26 μM, and 28.8 μM, respectively. It exhibits anti-inflammatory and anticancer properties and inhibits ATP hydrolysis while also blocking central synaptic transmission.
In vitro	Sodium metatungstate hydrate (100 μM, 15 min) inhibits ATP-induced anionic dye uptake and large pore formation in macrophages. Additionally, Sodium metatungstate hydrate (100 μM, 8 h) suppresses ATP-induced P2X7-related pyroptosis in macrophages. Furthermore, Sodium metatungstate hydrate (100 μM, 8-24 h) exhibits significant anti-inflammatory effects on macrophages.
In vivo	Sodium metatungstate hydrate (5 mg/kg, intraperitoneal injection, single dose) exhibits distinct cytokine/chemokine responses in the peritoneum and systemic circulation of CD39 knockout mice. Furthermore, when combined with anti-CD73 antibody and AZD4635, sodium metatungstate hydrate (5 mg/kg, intraperitoneal injection, once daily, from day 0 to day 4, day 7 to day 11, and day 14 to day 18) effectively reduces tumor burden in mice with multiple myeloma (MM).
Synonyms	Sodium polyoxotungstate hydrate, POM-1 hydrate

Chemical Properties

Molecular Weight	3004.01
Formula	H₄Na₆O₄₁W₁₂
Cas No.	314075-43-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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