Sodium metatungstate hydrate

Name: Sodium metatungstate hydrate
Brand: TargetMol
SKU: T208708
Rating: 4.5 (1 reviews)

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Catalog No. T208708Cas No. 314075-43-9

Alias Sodium polyoxotungstate hydrate, POM-1 hydrate

Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is an inhibitor of NTPDase, with Ki values for NTPDase1 (CD39), NTPDase 3, and NTPDase 2 being 2.58 μM, 3.26 μM, and 28.8 μM, respectively. It exhibits anti-inflammatory and anticancer properties and inhibits ATP hydrolysis while also blocking central synaptic transmission.

Sodium metatungstate hydrate

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Catalog No. T208708Alias Sodium polyoxotungstate hydrate, POM-1 hydrateCas No. 314075-43-9

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Sodium metatungstate (Sodium polyoxotungstate; POM-1) hydrate is an inhibitor of NTPDase, with Ki values for NTPDase1 (CD39), NTPDase 3, and NTPDase 2 being 2.58 μM, 3.26 μM, and 28.8 μM, respectively. It exhibits anti-inflammatory and anticancer properties and inhibits ATP hydrolysis while also blocking central synaptic transmission.
In vitro	Sodium metatungstate hydrate (100 μM, 15 min) inhibits ATP-induced anionic dye uptake and large pore formation in macrophages. Additionally, Sodium metatungstate hydrate (100 μM, 8 h) suppresses ATP-induced P2X7-related pyroptosis in macrophages. Furthermore, Sodium metatungstate hydrate (100 μM, 8-24 h) exhibits significant anti-inflammatory effects on macrophages.
In vivo	Sodium metatungstate hydrate (5 mg/kg, intraperitoneal injection, single dose) exhibits distinct cytokine/chemokine responses in the peritoneum and systemic circulation of CD39 knockout mice. Furthermore, when combined with anti-CD73 antibody and AZD4635, sodium metatungstate hydrate (5 mg/kg, intraperitoneal injection, once daily, from day 0 to day 4, day 7 to day 11, and day 14 to day 18) effectively reduces tumor burden in mice with multiple myeloma (MM).
Synonyms	Sodium polyoxotungstate hydrate, POM-1 hydrate

Chemical Properties

Molecular Weight	3004.01
Formula	H₄Na₆O₄₁W₁₂
Cas No.	314075-43-9
Smiles	O=[W+4]1234[O-2][W+4]567([O-2][W+4]89%10([O-2][W+4]%11%12([O-2]1)([O-2][W+4]%13([O-2]8)([O-2][W+4]%14%15%16([O-2][W+4]%17([O-2]2)([O-2]%11)([O-2][W+4]%18([O-2][W+4]([O-2]3)([O-2]5)([O-2][W+4]%19%20([O-2][W+4]%21([O-2]6)([O-2]9)([O-2][W+4]([O-2]%13)([O-2]%14)([O-2]%19)([OH-]%21%20)=O)=O)([O-2]%18)=O)([O-2]47)=O)([O-2]%15)([OH-]%17%16)=O)=O)=O)([O-2]%12%10)=O)=O)=O)=O.[Na+].O.[Na+].[Na+].[Na+].[Na+].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc