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Anti-Osteoprotegerin Polyclonal Antibody

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Catalog No. TMAB-01300
Alias tumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565

Anti-Osteoprotegerin Polyclonal Antibody is a Rabbit antibody targeting Osteoprotegerin. Anti-Osteoprotegerin Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.

Anti-Osteoprotegerin Polyclonal Antibody

Anti-Osteoprotegerin Polyclonal Antibody

😃Good
Catalog No. TMAB-01300Alias tumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565
Anti-Osteoprotegerin Polyclonal Antibody is a Rabbit antibody targeting Osteoprotegerin. Anti-Osteoprotegerin Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2227-10 days
100 μL$3737-10 days
200 μL$5287-10 days
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Product Introduction

Bioactivity
Description
Anti-Osteoprotegerin Polyclonal Antibody is a Rabbit antibody targeting Osteoprotegerin. Anti-Osteoprotegerin Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Aliastumor necrosis factor receptor superfamily member 11b, TR1, PDB5, OPG, OCIF, MGC29565
Ig Type
IgG
Reactivity
Human,Mouse,Rat (predicted:Dog,Cow)
Verified Activity
1. Tissue/cell: rat tibia tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer (0.01M, pH6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37°C for 20 min;
Incubation: Anti-Osteoprotegerin Polyclonal Antibody, Unconjugated (TMAB-01300) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAb staining.
2. Sample:
Heart (Mouse) Lysate at 40 μg
Kidney (Mouse) Lysate at 40 μg
Liver (Mouse) Lysate at 40 μg
Primary: Anti-OPg (TMAB-01300) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 43 kDa
Observed band size: 50 kDa
3. Sample:
Lane 1: Raji (Human) Cell Lysate at 30 μg
Lane 2: U251 (Human) Cell Lysate at 30 μg
Primary: Anti-OPG (TMAB-01300) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kDa
Observed band size: 55 kDa
Application
WB,IHC-P,IHC-Fr,IF
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Research BackgroundOsteoprotegerin (OPG, or osteoclastogenesis inhibitory factor) is a secretory glycoprotein belonging to TNF receptor superfamily. Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. OPG acts as a soluble factor in the regulation of bone mass and may be beneficial in the treatment of osteoporosis with increased osteoclast activity. OPG consists of 401 amino acids with a molecular weight of 44 kDa as a monomer and 90 kDa as a disulphide-linked dimer.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human OPG
Antigen Species
Human
Gene ID
Uniprot ID
Biology Area
Inflammatory mediators,Blood,Bone,TNF Superfamily,Obesity,Bone,TNF
Chemical Properties
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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