Isobutyl-deoxynyboquinone

Name: Isobutyl-deoxynyboquinone
Brand: TargetMol
SKU: T38901
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Catalog No. T38901Cas No. 1430798-22-3

Alias Isobutyl-deoxynyboquinone, IB-DNQ

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase [NQO1] and is utilized in anticancer research.

Isobutyl-deoxynyboquinone

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Catalog No. T38901Alias Isobutyl-deoxynyboquinone, IB-DNQCas No. 1430798-22-3

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase [NQO1] and is utilized in anticancer research.

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Product Introduction

Bioactivity

Description	Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase [NQO1] and is utilized in anticancer research.
In vitro	Isobutyl-deoxynyboquinone, at concentrations ranging from 0.01 to 100 μM, shows increased cytotoxic effectiveness against the SCCF1 and SCCF2 cell lines, with reduced potency in SCCF3 cells. Additionally, when applied to SCCF1 cells at doses between 0.1 to 3 μM for 60 minutes, it demonstrates dose-dependent cytotoxicity[1].
In vivo	Isobutyl-deoxynyboquinone, administered intravenously (i.v.) at dosages ranging from 0.5 to 2 mg/kg over a 20-hour period, successfully reaches average peak plasma concentrations in cats. Similarly, a dosage of 1 mg/kg administered orally (p.o.) attains peak plasma concentrations after 4 hours in the same animal model. Both administration routes and dosages were part of a pharmacokinetic analysis, indicating the compound's effective concentration levels in the blood following different methods of administration.
Synonyms	Isobutyl-deoxynyboquinone, IB-DNQ

Chemical Properties

Molecular Weight	326.352
Formula	C₁₈H₁₈N₂O₄
Cas No.	1430798-22-3
Smiles	CC(C)Cn1c2C(=O)c3[nH]c(=O)cc(C)c3C(=O)c2c(C)cc1=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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