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Trazodone hydrochloride

Name: Trazodone hydrochloride
Brand: TargetMol
SKU: T1619
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1619Cas No. 25332-39-2

Alias Trazodone HCl, KB-831, AF-1161

Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.

Trazodone hydrochloride

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Purity: 99.52%

Catalog No. T1619Alias Trazodone HCl, KB-831, AF-1161Cas No. 25332-39-2

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$40	In Stock	In Stock
1 g	$56	In Stock	In Stock
5 g	$137	-	In Stock
10 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.52%

Color:White

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Product Introduction

Trazodone hydrochloride AI Summary

Trazodone hydrochloride exhibits significant bioactivity across multiple biological targets and pathogens. It shows antiplasmodial activity against Plasmodium falciparum W2 with an IC50 of 10,000 nM after 72 hours using the SYBR green assay. Additionally, it inhibits human Jumonji Domain Containing 2E (JMJD2E) with potencies between 22,387.2 nM and 28,183.8 nM, and HSD17B4 (hydroxysteroid dehydrogenase 4) with a potency of 25,118.9 nM. The compound also differentially inhibits the proliferation of Plasmodium falciparum lines W2, GB4, and 7G8, with potencies ranging between 7,943.3 nM and 11,220.2 nM. Furthermore, Trazodone hydrochloride inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 25,118.9 nM, and HPGD (15-Hydroxyprostaglandin Dehydrogenase) with potencies between 28,183.8 nM and 35,481.3 nM. It effectively blocks chronic active B-cell receptor signaling at 6,513.1 nM and induces DNA re-replication in MCF 10a normal breast cells at a potency of 4.6 nM. The compound also inhibits Secretory Acid Sphingomyelinase (S-ASM) with a potency of 19,952.6 nM and shows variable efficacy in blocking Ebola Virus entry, with potencies ranging from 4,456.8 nM to 35,481.3 nM. In membrane vesicle transport assays, Trazodone hydrochloride shows weak or no inhibitory activity against human BSEP, MRP3, and MRP4 with IC50 values greater than 133,000.0 nM. It binds to human biotinylated HLA-A2 with a dissociation constant (Kd) of 2,500.0 nM as determined by surface plasmon resonance assay. Against SARS-CoV-2, Trazodone hydrochloride demonstrates inhibition of cell viability in Vero E6 cells at an MOI of 0.002 after 72 hours with an inhibition index of 0.9436. It also inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells by 4.71% at 10 µM after 48 hours and inhibits the SARS-CoV-2 3CL-Pro protease by 11.27% at 20 µM. However, its activity against SARS-CoV-2 induced cytotoxicity in Vero-6 cells at 10 µM is minimal (-0.13%). Additionally, Trazodone hydrochloride displays antifungal activity against Candida albicans and Cryptococcus neoformans with inhibition percentages of 3.08% and -5.73%, respectively. Its antibacterial activity varies, showing inhibition percentages of 0.18% against Escherichia coli, 4.82% against Klebsiella pneumoniae, 14.2% against Pseudomonas aeruginosa, 9.41% against Acinetobacter baumannii, and 11.44% against Staphylococcus aureus MRSA..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety.
Synonyms	Trazodone HCl, KB-831, AF-1161

Chemical Properties

Molecular Weight	408.33
Formula	C₁₉H₂₃Cl₂N₅O
Cas No.	25332-39-2
Smiles	Cl.Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 8.2 mg/mL (20.08 mM), Sonication is recommended.

DMSO: 33.33 mg/mL (81.63 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.45 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4490 mL	12.2450 mL	24.4900 mL	122.4500 mL
5 mM	0.4898 mL	2.4490 mL	4.8980 mL	24.4900 mL
10 mM	0.2449 mL	1.2245 mL	2.4490 mL	12.2450 mL
20 mM	0.1224 mL	0.6122 mL	1.2245 mL	6.1225 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4490 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc