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Iberin

Name: Iberin
Brand: TargetMol
SKU: T15544
Price: 59 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15544Cas No. 505-44-2

Alias NSC 321801

Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane.

Iberin

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Catalog No. T15544Alias NSC 321801Cas No. 505-44-2

Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$59	-	In Stock
5 mg	$136	-	In Stock
10 mg	$198	-	In Stock
25 mg	$328	-	In Stock
50 mg	$491	-	In Stock
100 mg	$716	-	In Stock
500 mg	$1,480	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane.
Targets&IC50	Cell survival:2.3 μM
In vitro	Iberin inhibits neuroblastoma cell growth in a dose- and time-dependent manner and inhibits the expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. Iberin increases the apoptotic cell death and activates caspase-9, caspase-3, and PARP[2].
In vivo	Iberin enhances tissue levels of the phase II detoxification enzymes quinone reductase and GST in a variety of rat tissues[5].
Synonyms	NSC 321801

Chemical Properties

Molecular Weight	163.26
Formula	C₅H₉NOS₂
Cas No.	505-44-2
Smiles	C(CS(C)=O)CN=C=S
Relative Density.	1.142 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 9 mg/mL (55.13 mM), Sonication is recommended.

DMSO: 279 mg/mL (1708.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (30.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1252 mL	30.6260 mL	61.2520 mL	306.2600 mL
5 mM	1.2250 mL	6.1252 mL	12.2504 mL	61.2520 mL
10 mM	0.6125 mL	3.0626 mL	6.1252 mL	30.6260 mL
20 mM	0.3063 mL	1.5313 mL	3.0626 mL	15.3130 mL
50 mM	0.1225 mL	0.6125 mL	1.2250 mL	6.1252 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0613 mL	0.3063 mL	0.6125 mL	3.0626 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc