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Alkaline phosphatase/ALPI Protein, Human, Recombinant (hFc)
(Synonyms: IAP, alkaline phosphatase, intestinal) Copy Product InfoSynonyms: IAP, alkaline phosphatase, intestinal
Catalog No. TMPY-02713 Copy Product Info
Alkaline phosphatase Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.5 kDa and the accession number is P09923.
| Pack Size | Price | EUR Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | 97 € | 7-10 days | 7-10 days | |
| 10 µg | 160 € | 7-10 days | 7-10 days | |
| 20 µg | 266 € | 7-10 days | 7-10 days | |
| 50 µg | 626 € | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: EUR Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to cleave a fluorogenic substrate, 4-Methylumbelliferyl phosphate (4-MUP). The specific activity is > 10,000 pmoles/min/μg. |
| Description | Alkaline phosphatase Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.5 kDa and the accession number is P09923. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P09923 |
| Construction | A DNA sequence encoding the mature form of human ALPI (P09923) (Met 1-Asp 503),without the pro peptide, was expressed with the fused Fc region of human IgG1 at the C-terminus. Predicted N terminal: Val 20 |
| Protein Purity | > 83 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | IAP, alkaline phosphatase, intestinal |
| Research Background | ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders. |
| Molecular Weight | 79.5 kDa (predicted); 90-95 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Alkaline phosphatase/ALPI Protein, Human, Recombinant (hFc) chemical structure | Alkaline phosphatase/ALPI Protein, Human, Recombinant (hFc) molecular weight
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