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Myosmine
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Catalog No. T7671Cas No. 532-12-7
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.
Myosmine
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Purity: 99.73%
Catalog No. T7671Cas No. 532-12-7
Myosmine is a minor tobacco alkaloid that is structurally related to nicotine.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $31 | - | In Stock | |
| 100 mg | $41 | In Stock | In Stock | |
| 200 mg | $67 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.73%
Appearance:Viscous
Color:Yellow
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Product Introduction
Myosmine AI Summary
Myosmine has a multifaceted profile with affinity and inhibitory activities. It demonstrates affinity for alpha4-beta2 nicotinic acetylcholine receptors in rat brain homogenates, excluding the cerebellum, with a Ki value of 3300.0 nM. In terms of its bioactivities, it acts as an inhibitor and substrate of Cytochrome P450 2C19 with a potency of 7943.3 nM, inhibits the interaction between the Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 with a potency of 199.5 nM, and impedes Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 12589.3 nM. It is also active in the Cytochrome P450 panel assay for cyp1a2 with an AC50 of 12589.25 nM.
Myosmine has two pKa values: 5.23 at 37°C and 5.5 at 25°C. It significantly displaces [3H]alpha-bungarotoxin from nicotinic acetylcholine receptors in bee and fly head membranes with a Ki greater than 1000000.0 nM and inhibits acetylcholinesterase in Musca domestica (house fly) with an IC50 of 6800000.0 nM. This compound also showcases insecticidal activity against Musca domestica (house fly) with a toxicity relative to nicotine (FC = 0.36).
Regarding its interactions with nicotinic acetylcholine receptors in Periplaneta americana (American cockroach), Myosmine inhibits these receptors by 27.3% at a 10 uM concentration over 2 hours at 24°C, with an IC50 greater than 10000.0 nM. For human CYP2A6 enzyme activity, the compound shows inhibitory action with an IC50 of 187,000.0 nM, affecting the enzyme-mediated 7-hydroxy coumarin formation.
Lastly, Myosmine exhibits antiviral activity against SARS-CoV-2, displayed through inhibition of virus-induced cytotoxicity in VERO-6 cells with reported IC50 values exceeding 20000.0 nM and 19952.62 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Myosmine is a minor tobacco alkaloid that is structurally related to nicotine. |
| Targets&IC50 | α4β2 nAChR:3300 nM (Ki), AT1:>10 µM (Ki) |
| Molecular Weight | 146.19 |
| Formula | C9H10N2 |
| Cas No. | 532-12-7 |
| Smiles | C1CN=C(C1)c1cccnc1 |
| Relative Density. | 1.12 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (75.24 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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