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Anti-SIRP alpha Antibody-APC (2F561)

🥰Excellent
Catalog No. TMAY-03500A

Anti-SIRP alpha Antibody-APC (2F561) is a APC-conjugated Rabbit antibody targeting SIRP alpha. Anti-SIRP alpha Antibody-APC (2F561) can be used in FCM.

Anti-SIRP alpha Antibody-APC (2F561)

Anti-SIRP alpha Antibody-APC (2F561)

🥰Excellent
Catalog No. TMAY-03500A
Anti-SIRP alpha Antibody-APC (2F561) is a APC-conjugated Rabbit antibody targeting SIRP alpha. Anti-SIRP alpha Antibody-APC (2F561) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-SIRP alpha Antibody-APC (2F561) is a APC-conjugated Rabbit antibody targeting SIRP alpha. Anti-SIRP alpha Antibody-APC (2F561) can be used in FCM.
Ig Type
Monoclonal Rabbit IgG
Clone
2F561
Reactivity
Mouse
Verified Activity
Flow cytometric analysis of Mouse SIRPA(CD172a) expression on BABL/c bone marrow cells. Cells were stained with APC-conjugated anti-Mouse SIRPA(CD172a). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Mouse SIRP alpha/SIRPA (rM SIRP alpha/SIRPA; TMPY-02632; BAA20376.1; Met1-Asn373) and conjugated with APC under optimum conditions, the unreacted APC was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.03%ProClin300
Research BackgroundTyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
APC
Others Formats
Unconjugated/FITC/PE
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Mouse SIRP alpha/SIRPA Protein (TMPY-02632)
Antigen Species
Mouse
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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