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PKG Substrate acetate(81187-14-6 free base)

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Catalog No. TP1787L

PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).

PKG Substrate acetate(81187-14-6 free base)
Other Forms of PKG Substrate acetate(81187-14-6 free base):
PKG SubstrateTP178781187-14-6
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PKG Substrate acetate(81187-14-6 free base)

🥰Excellent
Purity: 99.30%
Catalog No. TP1787L
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$43In StockIn Stock
5 mg$153In StockIn Stock
10 mg$230In StockIn Stock
25 mg$372In StockIn Stock
50 mg$498In StockIn Stock
100 mg$685In StockIn Stock
200 mg$903In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.30%
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COA MS HPLC

Product Introduction

Bioactivity
Description
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 μM) over PKG II (Km = 305 μM).
In vitro
Incorporation of [33P]ATP into the synthetic peptide PKG substrate RKRSRAE is measured. N6-benzyl-ATP inhibits kinase activity of PKG Iα gatekeeper mutants but not WT. The serotonin transporter (SERT) is responsible for reuptake of serotonin (5-hydroxytryptamine) after its exocytotic release from neurons. SERT is regulated by several processes, including a cyclic GMP signaling pathway involving nitric oxide synthase, guanylyl cyclase, and PKG[1].
Chemical Properties
Molecular Weight962.08
FormulaC37H71N17O13
SmilesCC(O)=O.O=C(O)CC[C@@H](C(O)=O)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)N)=O)=O)=O)=O)=O)=O
Relative Density.no data available
SequenceH-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH
Sequence ShortRKRSRAE
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

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