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Meclofenamic acid sodium

Name: Meclofenamic acid sodium
Brand: TargetMol
SKU: T0260
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0260Cas No. 6385-02-0

Alias Movens, Meclonax, Meclomen, Meclofenamate Sodium

Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Meclofenamic acid sodium

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Purity: 98.96%

Catalog No. T0260Alias Movens, Meclonax, Meclomen, Meclofenamate SodiumCas No. 6385-02-0

Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$45	In Stock	In Stock
100 mg	$77	In Stock	In Stock
200 mg	$126	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.96%

Color:White

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COA HNMR LCMS

Product Introduction

Meclofenamic acid sodium AI Summary

Meclofenamic acid sodium exhibits multiple bioactivities, notably inhibiting 5-lipoxygenase and Prostaglandin G/H synthase in the RBL-1 cell line with IC50 values of 24000.0 nM and 100.0 nM, respectively. It demonstrates significant anti-inflammatory effects, evidenced by a 40.8% inhibition of carrageenan-induced foot-pad edema at 30 mg/kg peroral administration and a 41.0% inhibition in the rat mycobacterium foot-pad edema test with an ID40 of 0.39 mg/kg. The compound also shows a ratio of IC50 for 5-lipoxygenase to Prostaglandin G/H synthase of 240.0. Additionally, Meclofenamic acid sodium inhibits soybean 15-lipoxygenase (15-LOX) using arachidonic acid and linoleic acid as substrates, with an IC50 of 5640.0 nM, and demonstrates 77.28% and 87.03% inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells, respectively, at 10 µM. Moreover, Meclofenamic acid sodium shows modest antifungal activity against Candida albicans and Cryptococcus neoformans, and varying antibacterial activity against a range of bacteria, including Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus MRSA. Its potency in both enzyme inhibitory and anti-inflammatory roles highlights its potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.
Targets&IC50	COX-1:40 nM, COX-2:50 nM
Synonyms	Movens, Meclonax, Meclomen, Meclofenamate Sodium

Chemical Properties

Molecular Weight	318.14
Formula	C₁₄H₁₀Cl₂NNaO₂
Cas No.	6385-02-0
Smiles	[NaH].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (157.16 mM), Sonication is recommended.

Ethanol: 59 mg/mL (185.45 mM), Sonication is recommended.

H2O: 58 mg/mL (182.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.29 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.1433 mL	15.7164 mL	31.4327 mL	157.1635 mL
5 mM	0.6287 mL	3.1433 mL	6.2865 mL	31.4327 mL
10 mM	0.3143 mL	1.5716 mL	3.1433 mL	15.7164 mL
20 mM	0.1572 mL	0.7858 mL	1.5716 mL	7.8582 mL
50 mM	0.0629 mL	0.3143 mL	0.6287 mL	3.1433 mL
100 mM	0.0314 mL	0.1572 mL	0.3143 mL	1.5716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc