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Anti-Serpin D1 Antibody (2E452)
😃Good
Catalog No. TMAY-03115
Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Anti-Serpin D1 Antibody (2E452) is a Rabbit antibody targeting Serpin D1. Anti-Serpin D1 Antibody (2E452) can be used in WB,ELISA,IP.
Anti-Serpin D1 Antibody (2E452)
Anti-Serpin D1 Antibody (2E452)
😃Good
Catalog No. TMAY-03115Alias Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Anti-Serpin D1 Antibody (2E452) is a Rabbit antibody targeting Serpin D1. Anti-Serpin D1 Antibody (2E452) can be used in WB,ELISA,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Serpin D1 Antibody (2E452) is a Rabbit antibody targeting Serpin D1. Anti-Serpin D1 Antibody (2E452) can be used in WB,ELISA,IP. |
| Alias | Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2E452 |
| Reactivity | Mouse |
| Verified Activity | 1. Mouse SERPIND1 was immunoprecipitated using: -Lane A:0.5 mg Hela Whole Cell Lysate -0.5 µL anti-Mouse SERPIND1 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-Mouse SERPIND1 rabbit monoclonal antibody, at 1:500 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 57 kDa. -Observed band size: 57 kDa. 2. Anti-SERPIND1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:57 kDa. -Observed band size:53 kDa |
| Application | WB,ELISA,IP |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:25000-1:50000; IP: 0.2-1 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SerpinD1 (rM SerpinD1; TMPY-01254; NP_032249.3; Met 1-Ser 478). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse SerpinD1 protein (TMPY-01254) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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