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Anti-Serpin D1 Antibody (2E452)
(Synonyms: Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900) Copy Product Info
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Synonyms: Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900
Catalog No. TMAY-03115 Copy Product Info
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Anti-Serpin D1 Antibody (2E452) is a Rabbit antibody targeting Serpin D1. Anti-Serpin D1 Antibody (2E452) can be used in ELISA,IP,WB.
Anti-Serpin D1 Antibody
(2E452)
(2E452)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $269 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Anti-Serpin D1 Antibody (2E452) is a Rabbit antibody targeting Serpin D1. Anti-Serpin D1 Antibody (2E452) can be used in ELISA,IP,WB. |
| Synonyms | Serpind1, serpin peptidase inhibitor, clade D (heparin cofactor), member 1, MGC107662, HCII, Hcf2, AI303446, AI30344 6, AA985900 |
| Ig Type | Rabbit IgG |
| Clone | 2E452 |
| Reactivity | Mouse |
| Specificity | Mouse SerpinD1 No cross-reactivity in ELISA with Human SerpinA1 / A1AT Human SerpinA3 / AACT Human SerpinA5 / PROCI Mouse SerpinF2 / AAP |
| Application | |
| Recommended Dose | WB: 1:500-1:1000; ELISA: 1:25000-1:50000; IP: 0.2-1 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SerpinD1 (rM SerpinD1; TMPY-01254; NP_032249.3; Met 1-Ser 478). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Mouse SerpinD1 protein (TMPY-01254) |
| Antigen Species | Mouse |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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