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AT-121 hydrochloride

🥰Excellent
Catalog No. T39529Cas No. 2099681-71-5

AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity. AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity.

AT-121 hydrochloride

AT-121 hydrochloride

🥰Excellent
Purity: 97.28%
Catalog No. T39529Cas No. 2099681-71-5
AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity. AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity.
Pack SizePriceAvailabilityQuantity
1 mg$350In Stock
5 mg$828In Stock
10 mg$1,130In Stock
25 mg$1,590In Stock
50 mg$1,980In Stock
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Bulk & Custom
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:97.28%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity. AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity.
In vivo
AT-121 hydrochloride (0.003-0.03 mg/kg; s.c.; Adult male and female rhesus monkeys) exhibited dose-dependent antinociceptive effects against acute noxious stimuli, specifically 50 °C water, thereby demonstrating potent antinociceptive activity. [1]
Chemical Properties
Molecular Weight499.11
FormulaC24H39ClN4O3S
Cas No.2099681-71-5
SmilesO=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4.Cl
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (100 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0036 mL10.0178 mL20.0357 mL100.1783 mL
5 mM0.4007 mL2.0036 mL4.0071 mL20.0357 mL
10 mM0.2004 mL1.0018 mL2.0036 mL10.0178 mL
20 mM0.1002 mL0.5009 mL1.0018 mL5.0089 mL
50 mM0.0401 mL0.2004 mL0.4007 mL2.0036 mL
100 mM0.0200 mL0.1002 mL0.2004 mL1.0018 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Keywords

OpioidReceptorOpioid ReceptorAT-121 HydrochlorideAT121 hydrochlorideAT121 HydrochlorideAT 121 HydrochlorideAT 121 hydrochloride
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