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AT-121 hydrochloride

Name: AT-121 hydrochloride
Brand: TargetMol
SKU: T39529
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39529Cas No. 2099681-71-5

AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity. AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity.

AT-121 hydrochloride

😃Good

Purity: 97.28%

Catalog No. T39529Cas No. 2099681-71-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$350	-	In Stock
5 mg	$828	-	In Stock
10 mg	$1,130	-	In Stock
25 mg	$1,590	-	In Stock
50 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:97.28%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity. AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and analgesic activity.
In vivo	AT-121 hydrochloride (0.003-0.03 mg/kg; s.c.; Adult male and female rhesus monkeys) exhibited dose-dependent antinociceptive effects against acute noxious stimuli, specifically 50 °C water, thereby demonstrating potent antinociceptive activity. [1]

Chemical Properties

Molecular Weight	499.11
Formula	C₂₄H₃₉ClN₄O₃S
Cas No.	2099681-71-5
Smiles	O=C1C2(C=3C(CN1CCNS(N)(=O)=O)=CC=CC3)CCN(CC2)[C@@H]4CC[C@H]([C@H](C)C)CC4.Cl

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (100.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0036 mL	10.0178 mL	20.0357 mL	100.1783 mL
5 mM	0.4007 mL	2.0036 mL	4.0071 mL	20.0357 mL
10 mM	0.2004 mL	1.0018 mL	2.0036 mL	10.0178 mL
20 mM	0.1002 mL	0.5009 mL	1.0018 mL	5.0089 mL
50 mM	0.0401 mL	0.2004 mL	0.4007 mL	2.0036 mL
100 mM	0.0200 mL	0.1002 mL	0.2004 mL	1.0018 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc