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lucPpy-IN-1

Catalog No. T78419 Copy Product Info
Purity: 99.79%
🥰Excellent
lucPpy-IN-1 (compound 9) is a potent inhibitor of the ATP-dependent luciferase from Photinus pyralis (lucPpy) with an IC50 value of 4.0 uM. Luciferase enzymes are widely utilized in bioluminescence-based reporter gene assays and high-throughput screening (HTS). lucPpy-IN-1 is primarily used to investigate the inhibitory effects of chemical libraries on firefly luciferase and to assist in assessing the druggability of targets, helping to identify and mitigate false-positive signals in HTS assays.

lucPpy-IN-1

Copy Product Info
🥰Excellent
Catalog No. T78419

lucPpy-IN-1 (compound 9) is a potent inhibitor of the ATP-dependent luciferase from Photinus pyralis (lucPpy) with an IC50 value of 4.0 uM. Luciferase enzymes are widely utilized in bioluminescence-based reporter gene assays and high-throughput screening (HTS). lucPpy-IN-1 is primarily used to investigate the inhibitory effects of chemical libraries on firefly luciferase and to assist in assessing the druggability of targets, helping to identify and mitigate false-positive signals in HTS assays.

lucPpy-IN-1
Cas No. 546100-66-7
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Pack SizePriceUSA StockGlobal StockQuantity
2 mg$30-In Stock
5 mg$46-In Stock
10 mg$85-In Stock
25 mg$172-In Stock
50 mg$253-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:99.79%
Appearance:Solid
Color:Orange
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Product Introduction

Bioactivity
Description
lucPpy-IN-1 (compound 9) is a potent inhibitor of the ATP-dependent luciferase from Photinus pyralis (lucPpy) with an IC50 value of 4.0 uM. Luciferase enzymes are widely utilized in bioluminescence-based reporter gene assays and high-throughput screening (HTS). lucPpy-IN-1 is primarily used to investigate the inhibitory effects of chemical libraries on firefly luciferase and to assist in assessing the druggability of targets, helping to identify and mitigate false-positive signals in HTS assays.
In vitro
lucPpy-IN-1 effectively inhibits lucPpy activity (IC50 = 4.0 uM), assisting in false positive identification in libraries [1].
Chemical Properties
Molecular Weight409.48
FormulaC25H23N5O
Cas No.546100-66-7
SmilesO=C(C1=CC(=NC=2C=CC=CC21)C=3C=CC(=CC3)C)N4CCN(C5=NC=CC=N5)CC4
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (244.21 mM), Sonication is recommmended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4421 mL12.2106 mL24.4212 mL122.1061 mL
5 mM0.4884 mL2.4421 mL4.8842 mL24.4212 mL
10 mM0.2442 mL1.2211 mL2.4421 mL12.2106 mL
20 mM0.1221 mL0.6105 mL1.2211 mL6.1053 mL
50 mM0.0488 mL0.2442 mL0.4884 mL2.4421 mL
100 mM0.0244 mL0.1221 mL0.2442 mL1.2211 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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