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Oxindole

Name: Oxindole
Brand: TargetMol
SKU: Fr16741
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. Fr16741Cas No. 59-48-3

Alias Indolin-2-one

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.

Oxindole

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Purity: 99.65%

Catalog No. Fr16741Alias Indolin-2-oneCas No. 59-48-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.65%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Oxindole AI Summary

Oxindole exhibits bioactivity influenced by its partition coefficient, with logP values varying under different conditions, suggesting different interactions with lipophilic environments. It demonstrates notable insecticidal activity against Plutella xylostella larvae (LC50 = 4832.5 ppm) and inhibits immune responses in Spodoptera exigua larvae, including hemocytic nodulation (IC50 = 32310.0 nM), phenoloxidase activity in hemolymph (IC50 = 51690.0 nM), and PLA2 activity in hemocytes (IC50 = 46250.0 nM). While it shows low potency for inhibiting recombinant human chymase (IC50 > 1000000.0 nM), it has antileishmanial activity against Leishmania infantum, affecting both axenic amastigotes and promastigotes, with notable therapeutic index values indicating relative safety and efficacy. Additionally, Oxindole inhibits human PDHK2 with an IC50 of 958,000.0 nM and exhibits some inhibitory activity against human PDHK4, with 29.0% inhibition observed relative to control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.
Synonyms	Indolin-2-one

Chemical Properties

Molecular Weight	133.15
Formula	C₈H₇NO
Cas No.	59-48-3
Smiles	O=C1CC2=C(N1)C=CC=C2
Relative Density.	1.1475 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (125.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.5103 mL	37.5516 mL	75.1033 mL	375.5163 mL
5 mM	1.5021 mL	7.5103 mL	15.0207 mL	75.1033 mL
10 mM	0.7510 mL	3.7552 mL	7.5103 mL	37.5516 mL
20 mM	0.3755 mL	1.8776 mL	3.7552 mL	18.7758 mL
50 mM	0.1502 mL	0.7510 mL	1.5021 mL	7.5103 mL
100 mM	0.0751 mL	0.3755 mL	0.7510 mL	3.7552 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc