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Oxindole

🥰Excellent
Catalog No. Fr16741Cas No. 59-48-3
Alias Indolin-2-one

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.

Oxindole

Oxindole

🥰Excellent
Purity: 99.65%
Catalog No. Fr16741Alias Indolin-2-oneCas No. 59-48-3
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.
Pack SizePriceAvailabilityQuantity
5 g$29In Stock
1 mL x 10 mM (in DMSO)$29In Stock
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Purity:99.65%
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Product Introduction

Bioactivity
Description
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.
SynonymsIndolin-2-one
Chemical Properties
Molecular Weight133.15
FormulaC8H7NO
Cas No.59-48-3
SmilesO=C1CC2=C(N1)C=CC=C2
Relative Density.1.1475 g/cm3 (Estimated)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16.67 mg/mL (125.17 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM7.5103 mL37.5516 mL75.1033 mL375.5163 mL
5 mM1.5021 mL7.5103 mL15.0207 mL75.1033 mL
10 mM0.7510 mL3.7552 mL7.5103 mL37.5516 mL
20 mM0.3755 mL1.8776 mL3.7552 mL18.7758 mL
50 mM0.1502 mL0.7510 mL1.5021 mL7.5103 mL
100 mM0.0751 mL0.3755 mL0.7510 mL3.7552 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OxindoleInhibitorinhibitHuman immunodeficiency virusHIVProteaseHIV ProteaseHIV
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