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Cell Cycle/Checkpoint

Nucleoside Antimetabolite/Analog

Poly(ADP-ribose) Glycohydrolase (PARG)

Serine/threonin kinase

(90)

Wee1

(31)

Y Box Binding Protein 1

(4)

c-Myc

(100)

APC/C

Anaphase Promoting Complex/Cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase complex that regulates the progression of the cell cycle, particularly during mitosis and the G1 phase. APC/C targets key cell cycle regulators, such as Securin and Cyclin B, for ubiquitin-mediated proteasomal degradation, thereby promoting the transition from metaphase to anaphase and the exit from mitosis. It ensures proper chromosome segregation by triggering the activation of Separase, which cleaves cohesin complexes holding sister chromatids together. APC/C activity is tightly regulated by co-activators like Cdc20 and Cdh1, which confer substrate specificity at different stages of the cell cycle. Dysfunction of APC/C can lead to chromosomal instability and is associated with various diseases, including cancer.

Filter HomeSignaling PathwaysCell Cycle/CheckpointAPC/C

Apcin

T8561300815-04-7

Apcin is a potent and competitive inhibitor of anaphase-promoting complex/cyclosome (APC/C(Cdc20)) E3 ligase activity. Apcin competitively inhibits APC/C-dependent ubiquitylation by binding to Cdc20 and preventing substrate recognition. It acts by blockin

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TAME hydrochloride

T17311784-03-8

TAME hydrochloride (Tos-Arg-OMe HCl) is a kind od amino acid derivatives.

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TASIN-1 Hydrochloride

T248551678515-13-3In house

TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

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TASIN-1

T22632792927-06-1

TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC).

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Apcin A HCL

T643391683535-53-6

Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to synthesize the PROTAC CP5V.

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TAME

T6693901-47-3

TAME (Tosyl-Arginine Methyl Este), an inhibitor of the late-promoting complex (APC/C or APC), inhibits APC-dependent protein hydrolysis by competing for APC binding with the C-terminal isoleucine-arginine tail of the APC activator cytokinesis cycle 20 (Cdc20). TAME binds to and prevents APC binding by Cdc20 and Cdh20. TAME binds to APC and prevents its activation by Cdc20 and Cdh1.

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Activated Protein C (390-404), human acetate

TP1628L

Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.

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CFM 4

T22646331458-02-7

CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.CFM 4 inhibits the growth of drug-resistant human breast cancer cells.

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ProTAME

T284551362911-19-0In house

ProTAME is an inhibitor of APC/CFzr and APC/CCdc20. Combinations of proTAME with topoisomerase inhibitors, doxorubicin and etoposide, significantly increase cell death in primary cells and Multiple Myeloma (MM) cell lines, particularly if TOPIIα levels are first increased through pre-treatment with ProTAME.This compound is unstable in powder form and other related salt forms are recommended.

$826

35 days

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Bovine Protein C

T205744

Bovine Protein C is activated into the serine protease activated protein C (APC) by α-thrombin or the α-thrombin thrombomodulin complex. It selectively inactivates factors Va and VIIIa, functioning as a potent anticoagulant.

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Apcin-A

T103451683617-62-0

Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be used to synthesize the PROTAC CP5V.

$169

5 days

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xStAx-VHLL

T36275

Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.

$1,980

35 days

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TASIN-30

T899271678515-93-9

TASIN-30 is an inhibitor of EBP, exhibiting a competitive EC50 value of 0.097 μM, and possesses a competitive EC50 value of 50 μM against DHCR7.

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10-14 weeks

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CDC20-IN-2

T207018

CDC20-IN-2 (14c) is an inhibitor of Cdc20 with a KD of 7.65 μM, inducing G2/M phase arrest, promoting DNA damage accumulation, and stabilizing key substrates such as Cyclin B1 and Bim. This leads to enhanced apoptosis, as well as inhibition of tumor cell proliferation and migration.

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