SUN 1334H

Name: SUN 1334H
Brand: TargetMol
SKU: T13040
Rating: 4.5 (1 reviews)

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Catalog No. T13040Cas No. 607736-84-5

SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM.

SUN 1334H

😃Good

Catalog No. T13040Cas No. 607736-84-5

SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	6-8 weeks	6-8 weeks
50 mg	Inquiry	6-8 weeks	6-8 weeks
100 mg	Inquiry	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	SUN 1334H is a potent, orally active, and highly selective H1 receptor antagonist with a Ki of 9.7 nM.
Targets&IC50	H1 receptor:ki： 9.7 nM
In vitro	In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2].
In vivo	In beagle dogs and in ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm for 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H significantly reduces passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effect models, SUN-1334H, desloratadine, and fexofenadine show no significant effects [2].

Chemical Properties

Molecular Weight	489.38
Formula	C₂₃H₂₈Cl₂F₂N₂O₃
Cas No.	607736-84-5
Smiles	Cl.Cl.OC(=O)COC\C=C\CN1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc