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YB-0158 ammonium
🥰Excellent
Catalog No. T38519L
Alias YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium
YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer.
YB-0158 ammonium
🥰Excellent
Purity: 99.18%
Catalog No. T38519LAlias YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium
YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $289 | In Stock | |
| 5 mg | $689 | In Stock | |
| 10 mg | $1,120 | In Stock | |
| 25 mg | $2,290 | In Stock | |
| 50 mg | $3,930 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.18%
ee:97.52%
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Product Introduction
Bioactivity
Chemical Properties
| Description | YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer. |
| Targets&IC50 | PDGFRα:210 nM, FGFR1:8 nM, VEGFR3/FLT4:8 nM, FGFR3:9 nM, VEGFR2:13 nM, FLT3:1 nM, PDGFRβ:27 nM, c-Kit:2 nM |
| In vitro | b>METHODS: YB-0158 ammonium (0.2 μM and 0.5 μM, 48 hours) treated HT29 cells RESULTS: Lower doses of YB-0158 ammonium were sufficient to significantly reduce the proliferation of human CRC cells. When used at 0.5 μM, YB-0158 ammonium also significantly increased the apoptosis of CRC cells, as measured by the activated Caspase-3/7 detection assay. represent. [1] |
| In vivo | b>METHODS: Primary mouse recipients were treated with YB-0158 ammonium (100 mg/kg), and the presence or absence of secondary tumors was determined by live fluorescence tumor imaging. RESULTS: No significant differences in primary tumor size were observed in YB-0158 ammonium-treated mice compared to saline controls. [1] |
| Synonyms | YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium |
| Molecular Weight | 693.69 |
| Formula | C32H40N9O7P |
| Smiles | [NH4+].[NH4+].[H][C@]12CN(Cc3cccc4cn[nH]c34)C(=O)[C@H](Cc3ccc(OP([O-])([O-])=O)cc3)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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