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YB-0158 ammonium
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Catalog No. T38519L
Alias YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium
YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer.
YB-0158 ammonium
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Purity: 99.18%
Catalog No. T38519LAlias YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium
YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $289 | - | In Stock | |
| 5 mg | $689 | - | In Stock | |
| 10 mg | $1,120 | - | In Stock | |
| 25 mg | $2,290 | - | In Stock | |
| 50 mg | $3,930 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.18%
ee:97.52%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | YB-0158 ammonium (Wnt pathway inhibitor 2 ammonium) is a reverse-rotation peptidomimetic small molecule with translation-enhancing potential and anticancer activity. YB-0158 ammonium disrupts Sam68-Src interaction and induces apoptosis in colorectal cancer cells, which can be used to study cancer. |
| Targets&IC50 | PDGFRβ:27 nM, FLT3:1 nM, FGFR1:8 nM, PDGFRα:210 nM, FGFR3:9 nM, c-Kit:2 nM, VEGFR2:13 nM, VEGFR3/FLT4:8 nM |
| In vitro | b>METHODS: YB-0158 ammonium (0.2 μM and 0.5 μM, 48 hours) treated HT29 cells RESULTS: Lower doses of YB-0158 ammonium were sufficient to significantly reduce the proliferation of human CRC cells. When used at 0.5 μM, YB-0158 ammonium also significantly increased the apoptosis of CRC cells, as measured by the activated Caspase-3/7 detection assay. represent. [1] |
| In vivo | b>METHODS: Primary mouse recipients were treated with YB-0158 ammonium (100 mg/kg), and the presence or absence of secondary tumors was determined by live fluorescence tumor imaging. RESULTS: No significant differences in primary tumor size were observed in YB-0158 ammonium-treated mice compared to saline controls. [1] |
| Synonyms | YB0158 ammonium, YB 0158 ammonium, Wnt pathway inhibitor 2 ammonium |
| Molecular Weight | 693.69 |
| Formula | C32H40N9O7P |
| Smiles | [NH4+].[NH4+].[H][C@]12CN(Cc3cccc4cn[nH]c34)C(=O)[C@H](Cc3ccc(OP([O-])([O-])=O)cc3)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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