Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50s of 0.033 μM, 0.19 μM, and 0.21 μM, respectively.JBSNF-000028 can drive insulin sensitization and weight loss. 000028 drives insulin sensitization, glucose regulation and weight loss and can be used to study metabolic disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 970.00 | |
10 mg | In stock | $ 1,200.00 | |
25 mg | In stock | $ 1,590.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 |
Description | JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50s of 0.033 μM, 0.19 μM, and 0.21 μM, respectively.JBSNF-000028 can drive insulin sensitization and weight loss. 000028 drives insulin sensitization, glucose regulation and weight loss and can be used to study metabolic disorders. |
Targets&IC50 | U2OS cells:2.5 μM (EC50) |
In vitro | In U2OS cells, JBSNF-000028 hydrochloride (24 h) inhibits NNMT activity with an EC50 of 2.5 μM[1]. JBSNF-000028 hydrochloride (10-100 μM; 72 h) shows no cytotoxicity against HepG2 cells[1]. JBSNF-000028 hydrochloride binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from the central domain)[1]. JBSNF-000028 hydrochloride is inactive against a broad panel of targets related to metabolism and safety[1]. |
In vivo | In mice with diet-induced obesity (DIO), JBSNF-000028 hydrochloride (50 mg/kg; oral; twice daily for 27 days) improves glucose and lipid handling[1]. JBSNF-000028 hydrochloride (50 mg/kg; oral; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1]. |
Synonyms | JBSNF-000028 free base |
Molecular Weight | 187.24 |
Formula | C11H13N3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.85 mg/mL (20.54 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JBSNF-000028 Others JBSNF-000028 free base inhibitor inhibit