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Anti-Carbonic Anhydrase 12 Antibody (7S411) is a Mouse antibody targeting Carbonic Anhydrase 12. Anti-Carbonic Anhydrase 12 Antibody (7S411) can be used in FCM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μL | $198 | 7-10 days |
Description | Anti-Carbonic Anhydrase 12 Antibody (7S411) is a Mouse antibody targeting Carbonic Anhydrase 12. Anti-Carbonic Anhydrase 12 Antibody (7S411) can be used in FCM. |
Alias | HsT18816, FLJ20151, CAXII, carbonic anhydrase XII, CA12 |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 7S411 |
Reactivity | Human |
Verified Activity | Flow cytometric analysis of Human CA12 expression on MCF-7 cells. Cells were stained with purified anti-Human CA12, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
Application | FCM |
Recommended Dose | FCM: 1:25-1:100 |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Carbonic Anhydrase XII (rh Carbonic Anhydrase XII; TMPY-00694; NP_001209.1; Met1-Gln291). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA12, also known as Car12 and carbonic anhydrase XII, is a type I membrane enzyme of an N-terminal extracellular catalytic domain, a membrane-spanning α-helix, and a small intracellular C-terminal domain. It is highly expressed in colon, kidney, prostate, intestine and activated lymphocytes and moderately expressed in pancreas, ovary, and testis. Overexpression of the CA12 is observed in certain human cancers and is used as a tumor marker. rmCA12 corresponds to the extracellular domain and has both carbonic anhydrase activity and esterase activity. |
Conjucates | Unconjugated |
Others Formats | FITC/PE |
Antibody Types Available | 3 |
Immunogen | Recombinant Human Carbonic Anhydrase XII protein (TMPY-00694) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
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