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BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $293 | In Stock | |
10 mg | $469 | In Stock | |
25 mg | $939 | In Stock | |
50 mg | $1,520 | In Stock | |
100 mg | $2,430 | In Stock | |
200 mg | $3,290 | In Stock |
Description | BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion. |
Targets&IC50 | Mitochondrial F₁F₀ ATP synthase:0.5 μM |
In vitro | BMS-199264 hydrochloride selectively inhibits the hydrolase activity of mitochondrial F₁F₀ ATP synthase in vitro (IC₅₀ = 0.5 μM), without significant effects on its synthase activity or ATP-sensitive potassium channels. [1] |
In vivo | BMS-199264 hydrochloride exhibited in an isolated rat heart ischemia model: hearts were pretreated with 3 μM BMS-199264 hydrochloride for 10 minutes before global ischemia. After 15 minutes of ischemia, mitochondrial F₁F₀ ATP synthase activity was measured, showing that BMS-199264 hydrochloride selectively inhibited hydrolase activity without affecting synthase function.[1] |
Alias | BMS199264 hydrochloride |
Molecular Weight | 567.53 |
Formula | C26H32Cl2N4O4S |
Cas No. | 186180-83-6 |
Smiles | N(CC=1NC=CN1)([C@@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(S(=O)(=O)N4CCCCC4)C3)C5=CC=C(Cl)C=C5.Cl |
Relative Density. | no data available |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (140.96 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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