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BMS-199264 hydrochloride

Name: BMS-199264 hydrochloride
Brand: TargetMol
SKU: T26843
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26843Cas No. 186180-83-6

Alias BMS199264 hydrochloride

BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.

BMS-199264 hydrochloride

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Purity: 99.86%

Catalog No. T26843Alias BMS199264 hydrochlorideCas No. 186180-83-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	-	In Stock
5 mg	$278	-	In Stock
10 mg	$446	-	In Stock
25 mg	$893	-	In Stock
50 mg	$1,450	-	In Stock
100 mg	$2,320	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

ee:100%

Appearance:Solid

Color:White

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COA CSFC HNMR IC LCMS ORP

Product Introduction

Bioactivity

Description	BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.
Targets&IC50	Mitochondrial F₁F₀ ATP synthase:0.5 μM
In vitro	BMS-199264 hydrochloride selectively inhibits the hydrolase activity of mitochondrial F₁F₀ ATP synthase in vitro (IC₅₀ = 0.5 μM), without significant effects on its synthase activity or ATP-sensitive potassium channels. [1]
In vivo	BMS-199264 hydrochloride exhibited in an isolated rat heart ischemia model: hearts were pretreated with 3 μM BMS-199264 hydrochloride for 10 minutes before global ischemia. After 15 minutes of ischemia, mitochondrial F₁F₀ ATP synthase activity was measured, showing that BMS-199264 hydrochloride selectively inhibited hydrolase activity without affecting synthase function.[1]
Synonyms	BMS199264 hydrochloride

Chemical Properties

Molecular Weight	567.53
Formula	C₂₆H₃₂Cl₂N₄O₄S
Cas No.	186180-83-6
Smiles	N(CC=1NC=CN1)([C@@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(S(=O)(=O)N4CCCCC4)C3)C5=CC=C(Cl)C=C5.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (140.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7620 mL	8.8101 mL	17.6202 mL	88.1011 mL
5 mM	0.3524 mL	1.7620 mL	3.5240 mL	17.6202 mL
10 mM	0.1762 mL	0.8810 mL	1.7620 mL	8.8101 mL
20 mM	0.0881 mL	0.4405 mL	0.8810 mL	4.4051 mL
50 mM	0.0352 mL	0.1762 mL	0.3524 mL	1.7620 mL
100 mM	0.0176 mL	0.0881 mL	0.1762 mL	0.8810 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc