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BMS-199264 hydrochloride

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Catalog No. T26843Cas No. 186180-83-6
Alias BMS199264 hydrochloride

BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.

BMS-199264 hydrochloride

BMS-199264 hydrochloride

🥰Excellent
Purity: 100%
Catalog No. T26843Alias BMS199264 hydrochlorideCas No. 186180-83-6
BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.
Pack SizePriceAvailabilityQuantity
1 mg$118 In Stock
5 mg$293 In Stock
10 mg$469 In Stock
25 mg$939 In Stock
50 mg$1,520 In Stock
100 mg$2,430 In Stock
200 mg$3,290 In Stock
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Purity:100%
ee:100%
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Product Introduction

Bioactivity
Description
BMS-199264 hydrochloride is the salt form of BMS-199264.BMS-199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase with an IC50=0.5 μM.BMS-199264 is able to inhibit the decline of ATP during myocardial ischemia, reduce myocardial necrosis, and enhance the recovery of myocardial contractile function after reperfusion.
Targets&IC50
Mitochondrial F₁F₀ ATP synthase:0.5 μM
In vitro
BMS-199264 hydrochloride selectively inhibits the hydrolase activity of mitochondrial F₁F₀ ATP synthase in vitro (IC₅₀ = 0.5 μM), without significant effects on its synthase activity or ATP-sensitive potassium channels. [1]
In vivo
BMS-199264 hydrochloride exhibited in an isolated rat heart ischemia model: hearts were pretreated with 3 μM BMS-199264 hydrochloride for 10 minutes before global ischemia. After 15 minutes of ischemia, mitochondrial F₁F₀ ATP synthase activity was measured, showing that BMS-199264 hydrochloride selectively inhibited hydrolase activity without affecting synthase function.[1]
AliasBMS199264 hydrochloride
Chemical Properties
Molecular Weight567.53
FormulaC26H32Cl2N4O4S
Cas No.186180-83-6
SmilesN(CC=1NC=CN1)([C@@H]2C=3C(OC(C)(C)[C@H]2O)=CC=C(S(=O)(=O)N4CCCCC4)C3)C5=CC=C(Cl)C=C5.Cl
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (140.96 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7620 mL8.8101 mL17.6202 mL88.1011 mL
5 mM0.3524 mL1.7620 mL3.5240 mL17.6202 mL
10 mM0.1762 mL0.8810 mL1.7620 mL8.8101 mL
20 mM0.0881 mL0.4405 mL0.8810 mL4.4051 mL
50 mM0.0352 mL0.1762 mL0.3524 mL1.7620 mL
100 mM0.0176 mL0.0881 mL0.1762 mL0.8810 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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