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QX-222 chloride

Name: QX-222 chloride
Brand: TargetMol
SKU: T23213
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23213Cas No. 5369-00-6

Alias QX 222 hloride, Lidocaine N-Methyl Hydrochloride

QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.

QX-222 chloride

🥰Excellent

Purity: 97.37%

Catalog No. T23213Alias QX 222 hloride, Lidocaine N-Methyl HydrochlorideCas No. 5369-00-6

QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.

Pack Size	Price	Availability
25 mg	$52	In Stock
50 mg	$96	In Stock
100 mg	$156	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:97.37%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.
In vivo	Intravenous infusion administration of 10 mg/kg QX-222 chloride for 7 days reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats[2].
Synonyms	QX 222 hloride, Lidocaine N-Methyl Hydrochloride

Chemical Properties

Molecular Weight	256.77
Formula	C₁₃H₂₁ClN₂O
Cas No.	5369-00-6
Smiles	[Cl-].Cc1cccc(C)c1NC(=O)C[N+](C)(C)C
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (389.45 mM), Sonication and heating to 60℃ are recommended.

H2O: 100 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (15.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8945 mL	19.4727 mL	38.9454 mL	194.7268 mL
5 mM	0.7789 mL	3.8945 mL	7.7891 mL	38.9454 mL
10 mM	0.3895 mL	1.9473 mL	3.8945 mL	19.4727 mL
20 mM	0.1947 mL	0.9736 mL	1.9473 mL	9.7363 mL
50 mM	0.0779 mL	0.3895 mL	0.7789 mL	3.8945 mL
100 mM	0.0389 mL	0.1947 mL	0.3895 mL	1.9473 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc