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QC-01-175
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Catalog No. T210413Cas No. 2267290-96-8
Alias QC 01 175
QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases.
QC-01-175
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Purity: 98.95%
Catalog No. T210413Alias QC 01 175Cas No. 2267290-96-8
QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | - | In Stock | |
| 5 mg | $163 | - | In Stock | |
| 10 mg | $239 | - | In Stock | |
| 25 mg | $428 | - | In Stock | |
| 50 mg | $645 | - | In Stock | |
| 100 mg | $969 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $227 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.95%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases. |
| In vitro | In SH-SY5Y cells treated with ALS synaptosomes (ALS SNs), QC-01-175 (1-10 μM) reduces the levels of hyperphosphorylated Tau, specifically the pTau-S396 variant. Treatment with 10 μM QC-01-175 for 4 hours is associated with a reduction in mitochondrial fragmentation and a decrease in oxidative stress induced by ALS SNs. In FTD patient-derived neuronal cell models, the molecule has demonstrated the capacity to degrade aberrant Tau species [1][2]. |
| Synonyms | QC 01 175 |
| Molecular Weight | 626.66 |
| Formula | C33H34N6O7 |
| Cas No. | 2267290-96-8 |
| Smiles | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCNC(=O)CCC=4C=CC5=C(C4)NC6=CC=NC=C65)C3C2=O)CC1 |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (127.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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