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QC-01-175
😃Good
Catalog No. T210413Cas No. 2267290-96-8
Alias QC 01 175
QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases.
QC-01-175
😃Good
Purity: 98.95%
Catalog No. T210413Alias QC 01 175Cas No. 2267290-96-8
QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | - | In Stock | |
| 5 mg | $163 | - | In Stock | |
| 10 mg | $239 | - | In Stock | |
| 25 mg | $428 | - | In Stock | |
| 50 mg | $645 | - | In Stock | |
| 100 mg | $969 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $227 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.95%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | QC-01-175 is a heterobifunctional small molecule specifically designed to induce degradation of aberrant tau protein, and it effectively reduces levels of A152T and P301L mutant tau, protects neurons from tau-mediated cytotoxicity. QC-01-175 significantly improves neuronal survival, thereby providing a valuable chemical biology tool for studying tauopathies and developing targeted protein degradation strategies for neurodegenerative diseases. |
| In vitro | In SH-SY5Y cells treated with ALS synaptosomes (ALS SNs), QC-01-175 (1-10 μM) reduces the levels of hyperphosphorylated Tau, specifically the pTau-S396 variant. Treatment with 10 μM QC-01-175 for 4 hours is associated with a reduction in mitochondrial fragmentation and a decrease in oxidative stress induced by ALS SNs. In FTD patient-derived neuronal cell models, the molecule has demonstrated the capacity to degrade aberrant Tau species [1][2]. |
| Synonyms | QC 01 175 |
| Molecular Weight | 626.66 |
| Formula | C33H34N6O7 |
| Cas No. | 2267290-96-8 |
| Smiles | O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCOCCNC(=O)CCC=4C=CC5=C(C4)NC6=CC=NC=C65)C3C2=O)CC1 |
| Color | Yellow |
| Appearance | Solid |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (127.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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