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(S)-CCG-1423

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Catalog No. T23296

(S)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A and serum response factor.

(S)-CCG-1423
Other Forms of (S)-CCG-1423:

(S)-CCG-1423

😃Good
Catalog No. T23296
(S)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A and serum response factor.
Pack SizePriceAvailabilityQuantity
5 mg$2636-8 weeks
10 mg$5006-8 weeks
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Product Introduction

Bioactivity
Description
(S)-CCG-1423 is a stereoisomer of CCG-1423. CCG-1423 is a Rho inhibitor involved in blocking signaling through myocardin-related transcription factor A and serum response factor.
In vitro
CCG-14223 was an inhibitor for Rho/SRF pathway and displayed activity in several in vitro cancer cell functional assays. In PC-3 prostate cancer cells, CCG-1423(< 1 μmol/L) potently inhibited lysophosphatidic acid-induced DNA synthesis. CCG-1423 inhibited the growth of RhoC-overexpressing melanoma lines at nanomolar concentrations. CCG-1423 selectively stimulated apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line when compared with the parental cell line. CCG-1423 inhibited Rho-dependent invasion by PC-3 prostate cancer cells. The S-isomer of CCG-1423 inhibited MRTF-A-dependent cellular events, including SRF-mediated gene expression and cell migration. The efficacy of (S)-CCG-1423 was more potent than the R-isomer [1][2].
Chemical Properties
Molecular Weight454.8
FormulaC18H13ClF6N2O3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: ≤0.25 mg/mL, Sonication is recommended.
DMSO: 10 mg/mL (21.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1988 mL10.9938 mL21.9877 mL109.9384 mL
5 mM0.4398 mL2.1988 mL4.3975 mL21.9877 mL
10 mM0.2199 mL1.0994 mL2.1988 mL10.9938 mL
20 mM0.1099 mL0.5497 mL1.0994 mL5.4969 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

CCG-1423CCG 1423(S) CCG 1423CCG1423(S)CCG1423
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