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2,3-Butanedione 2-Monoxime

Name: 2,3-Butanedione 2-Monoxime
Brand: TargetMol
SKU: T2176
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2176Cas No. 57-71-6

Alias Diacetyl monoxime, 2,3-Butanedione-2-monoxime

2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.

2,3-Butanedione 2-Monoxime

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Purity: 98.77%

Catalog No. T2176Alias Diacetyl monoxime, 2,3-Butanedione-2-monoximeCas No. 57-71-6

2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

2,3-Butanedione 2-Monoxime AI Summary

2,3-Butanedione 2-Monoxime exhibits a range of bioactivities, showing potency in inhibiting mitochondrial division or activating mitochondrial fusion, as well as modulating human peripheral Myelin Protein 22 expression/activity, inhibiting Bloom's syndrome helicase (BLM), Neuropeptide S Receptor cAMP signal transduction, GCN5L2, Histone Lysine Methyltransferase G9a, Pin1, ELG1-dependent DNA repair, Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), and the binding or entry of Marburg Virus. It also demonstrates potency in inhibiting the interaction of thyroid hormone receptor and steroid receptor coregulator 2, and enhances Arylsulfatase A (ASA1) activity. Additionally, it exhibits a dissociation constant (pKa) of 9.5, a log P of 0.48 in octanol-phosphate buffer lipophilicity at pH 7.6, a binding affinity (Kd) of 392600.0 nM to paraoxon-inhibited AChE, and a maximum reactivation of 20.0% of paraoxon-inhibited AChE. Furthermore, it has a permeability of 6.0 x 10^-6 cm/s as assessed by the PAMPA assay, indicating its potential bioavailability and ability to reach target cells or tissues..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.
Synonyms	Diacetyl monoxime, 2,3-Butanedione-2-monoxime

Chemical Properties

Molecular Weight	101.1
Formula	C₄H₇NO₂
Cas No.	57-71-6
Smiles	C(C(C)=O)(=NO)C
Relative Density.	1.2085 g/cm3 (Estimated)

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (494.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (19.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	9.8912 mL	49.4560 mL	98.9120 mL	494.5598 mL
5 mM	1.9782 mL	9.8912 mL	19.7824 mL	98.9120 mL
10 mM	0.9891 mL	4.9456 mL	9.8912 mL	49.4560 mL
20 mM	0.4946 mL	2.4728 mL	4.9456 mL	24.7280 mL
50 mM	0.1978 mL	0.9891 mL	1.9782 mL	9.8912 mL
100 mM	0.0989 mL	0.4946 mL	0.9891 mL	4.9456 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc