AlbA-DCA

Name: AlbA-DCA
Brand: TargetMol
SKU: T13538
Rating: 4.5 (1 reviews)

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Catalog No. T13538

AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.

AlbA-DCA

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Catalog No. T13538

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	Inquiry	Inquiry	Inquiry
500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	AlbA-DCA, a conjugate of Albiziabioside A and a dichloroacetate acid subunit, markedly increases intracellular ROS, alleviates lactic acid accumulation in the tumor microenvironment, selectively kills cancer cells, and induces apoptosis.
In vitro	AlbA-DCA exhibits cytotoxicity against MCF-7, HCT116, A375, 4T1, HBMEC, and LO2 cells (IC50s: 0.43 μM, 3.87 μM, 3.78 μM, 1.31 μM, 38.20 μM, and 53.14 μM, respectively). Treatment with AlbA-DCA (2 μM; 24 hours) induces apoptosis in MCF-7 cells, significantly up-regulating cytochrome c expression, down-regulating Bcl-2 expression, and enhancing caspase-9 expression.
In vivo	AlbA-DCA (2 mg/kg; subcutaneous injection; every 2 days; for 2 weeks; nude mice) demonstrates significant antitumor efficacy, nearly completely inhibiting tumor progression with no observed mortality or significant changes in body weight. Additionally, AlbA-DCA exhibits no apparent toxicity in the liver and kidney, nor any major abnormalities in the heart, liver, spleen, lung, and kidney.

Chemical Properties

Molecular Weight	860.9
Formula	C₄₃H₆₇Cl₂NO₁₂
Smiles	O[C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)NC(C(Cl)Cl)=O)O[C@H]2CC[C@]3(C(C2(C)C)CC[C@@]4(C3CC=C5[C@]4(CC[C@@]6(C5CC(C)(CC6)C)C(O)=O)C)C)C)CO[C@@H]7OC[C@@H]([C@@H]([C@H]7O)O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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