SIGIRR Protein, Human, Recombinant (hFc)

Name: SIGIRR Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-03529
Rating: 4.5 (1 reviews)

(Synonyms: TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) Copy Product Info

Synonyms: TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Catalog No. TMPY-03529 Copy Product Info

SIGIRR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.29 kDa and the accession number is Q6IA17-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$359	7-10 days	7-10 days
100 µg	$696	7-10 days	7-10 days
200 µg	$1,060	7-10 days	7-10 days
500 µg	$2,230	7-10 days	7-10 days
1 mg	$4,530	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity testing is not tested. It is theoretically active, but we cannot guarantee it.
Description	SIGIRR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.29 kDa and the accession number is Q6IA17-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q6IA17-1
Construction	Met1-His118
Protein Purity	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	TIR8, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Research Background	TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-_x005f_x0001_B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.

Chemical Properties

Molecular Weight

39.29 kDa (Predicted); 50-70 kDa (Due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.