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Anti-MICA Antibody-APC (3K607) is a APC-conjugated Mouse antibody targeting MICA. Anti-MICA Antibody-APC (3K607) can be used in FCM.
Description | Anti-MICA Antibody-APC (3K607) is a APC-conjugated Mouse antibody targeting MICA. Anti-MICA Antibody-APC (3K607) can be used in FCM. |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 3K607 |
Reactivity | Human |
Verified Activity | Profile of anti-MICA reactivity on HeLa cells analyzed by flow cytometry. |
Application | FCM |
Recommended Dose | 5 μl/Test, 0.1 mg/ml |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MICA (rh MICA; TMPY-02053; AAH16929.1; Met 1-Gln 308) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
Purification | Protein A |
Appearance | Liquid |
Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
Research Background | MHC class I chain-related molecules A (MICA) is one of the genes in the HLA class I region, which belongs to the MHC class I family. It is the member of the non-classical class I family that displays the greatest degree of polymorphism. The MICA protein product is expressed on the cell surface, although unlike canonical class I molecules do not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. The Natural killer group 2D (NKG2D), a C-type lectin-like activating immunoreceptor, is a receptor of MICA, which was detected on most gamma-delta T cells, CD8+ alpha-beta T cells, and natural killer (NK) cells. Effector cells from all these subsets could be stimulated by the ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of gamma-delta T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. The MICA system is a novel, avidin-free immunohistochemical detection system that provides a significant increase in sensitivity compared to traditional immunodetection systems. |
Conjucates | APC |
Others Formats | Unconjugated/FITC/PE |
Antibody Types Available | 4 |
Immunogen | Recombinant Human MICA protein (TMPY-02053) |
Antigen Species | Human |
Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
Transport | Shipping with blue ice. |
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