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Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody
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Catalog No. TMAB-06856
Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Guanylyl Cyclase alpha 1. Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody
Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-06856
Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Guanylyl Cyclase alpha 1. Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody is a Rabbit antibody targeting Guanylyl Cyclase alpha 1. Anti-Guanylyl Cyclase alpha 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Rabbit) |
| Verified Activity | Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-GCS alpha 1 Polyclonal Antibody, Unconjugated (TMAB-06856) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble forms, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor forms, known as GC, are peptide hormone receptors. GCS, a cGMP-synthesizing enzyme, is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one alpha subunit, designated GCS-alpha-1, and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both the alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. |
| Immunogen | KLH conjugated synthetic peptide: human Guanylyl Cyclase alpha 1 |
| Antigen Species | Human |
| Gene Name | GUCY1A1 |
| Gene ID | |
| Protein Name | Guanylate cyclase soluble subunit alpha-1 |
| Uniprot ID |
| Molecular Weight | Theoretical: 77 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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