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DL-Carnitine

Name: DL-Carnitine
Brand: TargetMol
SKU: T0743
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0743Cas No. 461-06-3

Alias Carnitine, Carnitina

DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias.

DL-Carnitine

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Purity: 99.75%

Catalog No. T0743Alias Carnitine, CarnitinaCas No. 461-06-3

DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	In Stock	In Stock
50 mg	$39	In Stock	In Stock
100 mg	$56	In Stock	In Stock
200 mg	$83	In Stock	In Stock
500 mg	$140	-	In Stock
1 g	$198	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

DL-Carnitine AI Summary

DL-Carnitine exhibits multiple bioactivities related to various transporters and antiviral properties. It demonstrates a high affinity for carnitine/acylcarnitine translocase with a 94.19% translocation efficiency at a 3 mM concentration and strong inhibition of human MRP2-mediated estradiol-17-beta-glucuronide transport, reducing activity to 84.0%. Predicted as non-hepatotoxic by the Drug Induced Liver Injury Prediction System, it has a HepSE score of 0.0 for different liver conditions. It acts as a substrate for OCTN2 transporters in HEK293 cells with a Km of 2660.0 nM and exhibits a Km of 54000.0 nM in RBE4 cells. The compound also affects TEA and carnitine uptake in Xenopus laevis oocytes, showing inhibition at specified concentrations. Moreover, DL-Carnitine inhibits several liver transporters, including OATP1B1 by 36.6% and minimally affects OATP2B1 and OATP1B3. It reduces BSEP activity with an IC50 value greater than 1000000.0 nM. Additionally, it has moderate to weak antiviral activity against SARS-CoV-2 in Vero E6 cells, with an IC50 value greater than 20000.0 nM, indicating its lower potency compared to arbidol control..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Carnitine (Carnitina) is the constituent of liver and striated muscle. In therapeutically It is used to stimulate pancreatic and gastric secretions and to treat hyperlipoproteinemias.
Synonyms	Carnitine, Carnitina

Chemical Properties

Molecular Weight	161.2
Formula	C₇H₁₅NO₃
Cas No.	461-06-3
Smiles	C[N+](C)(C)CC(O)CC(=O)[O-]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (155.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2035 mL	31.0174 mL	62.0347 mL	310.1737 mL
5 mM	1.2407 mL	6.2035 mL	12.4069 mL	62.0347 mL
10 mM	0.6203 mL	3.1017 mL	6.2035 mL	31.0174 mL
20 mM	0.3102 mL	1.5509 mL	3.1017 mL	15.5087 mL
50 mM	0.1241 mL	0.6203 mL	1.2407 mL	6.2035 mL
100 mM	0.0620 mL	0.3102 mL	0.6203 mL	3.1017 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc