Shopping Cart

Your shopping cart is currently empty

D-Desthiobiotin

Name: D-Desthiobiotin
Brand: TargetMol
SKU: T19259
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T19259Cas No. 533-48-2

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, as well as for protein and cell labeling, detection, and separation.

D-Desthiobiotin

Copy Product Info

🥰Excellent

Purity: 99.90%

Catalog No. T19259Cas No. 533-48-2

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, as well as for protein and cell labeling, detection, and separation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$30	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.90%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

D-Desthiobiotin AI Summary

D-Desthiobiotin exhibits a variety of bioactivities across several targets. It has an IC50 of 1378.0 nM in a TR-FRET-based assay for agonists of the interaction between PPARg and NCOR2, and shows potency of 1000.0 nM in inhibiting the JMJD2A-Tudor Domain. The compound also has an IC50 of 1570.0 nM in a discovery assay for H1N1 Influenza NS1A-related probes. In a counterscreen for IDE activators, D-Desthiobiotin has an EC50 of 7406.0 nM and an IC50 greater than 89166.0 nM. Additionally, it demonstrates potency in inhibiting activities related to Polymerase Eta, TGF-b, and WRN Helicase. Furthermore, it shows significant bioactivity as an inhibitor of avidin with an exceptionally low Ki value of 0.00041 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

D-Desthiobiotin is a biotin derivative used in affinity chromatography and protein chromatography, as well as for protein and cell labeling, detection, and separation.

Chemical Properties

Molecular Weight	214.26
Formula	C₁₀H₁₈N₂O₃
Cas No.	533-48-2
Smiles	C(CCCCC(O)=O)[C@@H]1[C@H](C)NC(=O)N1
Relative Density.	1.095g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (186.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6672 mL	23.3361 mL	46.6723 mL	233.3613 mL
5 mM	0.9334 mL	4.6672 mL	9.3345 mL	46.6723 mL
10 mM	0.4667 mL	2.3336 mL	4.6672 mL	23.3361 mL
20 mM	0.2334 mL	1.1668 mL	2.3336 mL	11.6681 mL
50 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6672 mL
100 mM	0.0467 mL	0.2334 mL	0.4667 mL	2.3336 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc