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UNC9994 hydrochloride

Name: UNC9994 hydrochloride
Brand: TargetMol
SKU: T62853
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T62853 Copy Product Info

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UNC9994 hydrochloride is a functionally selective, beta-arrestin-biased dopamine D2 receptor (D2R) agonist with a Ki of 79 nM for D2R binding. UNC9994 hydrochloride also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/beta-arrestin-2 interactions, exhibiting potent antipsychotic-like activity.

UNC9994 hydrochloride

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Catalog No. T62853

Cas No. 2108826-33-9

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$74	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	UNC9994 hydrochloride is a functionally selective, beta-arrestin-biased dopamine D2 receptor (D2R) agonist with a Ki of 79 nM for D2R binding. UNC9994 hydrochloride also acts as an antagonist of Gi-regulated cAMP production and a partial agonist for D2R/beta-arrestin-2 interactions, exhibiting potent antipsychotic-like activity.
Targets&IC50	5-HT1A receptor:26 nM (Ki), 5-HT2A receptor:140 nM (Ki), D1 receptor:4000 nM (Ki)
In vitro	In vitro, UNC9994 hydrochloride induces D2-mediated beta-arrestin-2 translocation with EC50 values of 6.1 nM (Tango assay) and 448 nM (DiscoveRx assay). It acts as an antagonist for 5-HT2A and 5-HT2B receptors while serving as an agonist for 5-HT2C and 5-HT1A receptors [1].
In vivo	In vivo, intraperitoneal administration of UNC9994 hydrochloride (2.0 mg/kg) markedly inhibits phencyclidine (PCP)-induced hyperlocomotion in wild-type mice. This antipsychotic-like activity is completely abolished in beta-arrestin-2 knockout mice, demonstrating that its effects are dependent on the beta-arrestin-2 signaling pathway [1].

Chemical Properties

Molecular Weight	457.84
Formula	C₂₁H₂₃Cl₃N₂OS
Cas No.	2108826-33-9
Smiles	Cl.ClC1=CC=CC(=C1Cl)C2CCN(CCCOC=3C=CC=4SC=NC4C3)CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (174.73 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1842 mL	10.9208 mL	21.8417 mL	109.2085 mL
5 mM	0.4368 mL	2.1842 mL	4.3683 mL	21.8417 mL
10 mM	0.2184 mL	1.0921 mL	2.1842 mL	10.9208 mL
20 mM	0.1092 mL	0.5460 mL	1.0921 mL	5.4604 mL
50 mM	0.0437 mL	0.2184 mL	0.4368 mL	2.1842 mL
100 mM	0.0218 mL	0.1092 mL	0.2184 mL	1.0921 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc