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Kallikrein 2/KLK2 Protein, Human, Recombinant (His)
(Synonyms: Tissue Kallikrein-2, KLK2, Kallikrein-2, hGK-1, Glandular Kallikrein-1) Copy Product InfoSynonyms: Tissue Kallikrein-2, KLK2, Kallikrein-2, hGK-1, Glandular Kallikrein-1
Catalog No. TMPJ-00891 Copy Product Info
Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $112 | - | In Stock | |
| 10 µg | $183 | - | In Stock | |
| 20 µg | $292 | - | In Stock | |
| 50 µg | $545 | - | In Stock | |
| 100 µg | $813 | - | In Stock | |
| 200 µg | $1,190 | 7-10 days | 7-10 days | |
| 500 µg | $2,070 | 7-10 days | 7-10 days | |
| 1 mg | $2,970 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SDS-PAGE); 97% (SEC-HPLC)
Appearance:Solution
Color:Transparent
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to cleave a flourogenic peptide substrate Z-Phe-Arg-AMC. The specific activity is 145 pmol/min/μg. (Regularly tested) Immobilized Recombinant Human KLK2 (C-6His) at 1 μg/ml (100 μl/well) can bind Anti-Human KLK2 antibody (Human IgG1). The ED50 of Anti-Human KLK2 antibody (Human IgG1) is 7.06 ng/ml.(Regularly tested) Loaded Anti-Human KLK2 antibody on Pro-A Biosensor, can bind Recombinant Human KLK2 with an affinity constant of 34.4 nM as determined in BLI assay. (Regularly tested) |
| Description | Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-6xHis |
| Accession Number | P20151 |
| Amino Acid | Pro19-Pro261 |
| Construction | Pro19-Pro261 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. Greater than 95% as determined by SEC-HPLC. |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM Acetate, 250 mM Trehalose, 0.02% Tween 80, pH5.0. |
| Synonyms | Tissue Kallikrein-2, KLK2, Kallikrein-2, hGK-1, Glandular Kallikrein-1 |
| Research Background | Kallikrein-2 (KLK2) is a secreted serine protease that belongs to the peptidase S1 family of Kallikrein subfamily. KLK2 contains 1 peptidase S1 domain. It is highly expressed in the human prostate gland. KLK2 can cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin, but Preferential cleavages of Arg-|-Xaa bonds in small molecule substrates. It also highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen. KLK2 is considered to be a biomarker for prostate cancer. |
| Molecular Weight | (10-12)&(16-19)&(28-33) KDa (reducing condition) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: Kallikrein 2/KLK2 Protein, Human, Recombinant (His) chemical structure | Kallikrein 2/KLK2 Protein, Human, Recombinant (His) molecular weight
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