HDAC-IN-98

Name: HDAC-IN-98
Brand: TargetMol
SKU: T212796
Rating: 4.5 (1 reviews)

Catalog No. T212796 Copy Product Info

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HDAC-IN-98 is an inhibitor of HDAC1, HDAC2, and HDAC3, with IC₅₀ values of 41.2 nM, 52.5 nM, and 74.3 nM, respectively. HDAC-IN-98 induces H3K9 acetylation, upregulates p21 expression, causes G2/M phase arrest, and induces apoptosis, making it suitable for research on epigenetic regulation in tumors.

HDAC-IN-98

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Catalog No. T212796

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Product Introduction

Bioactivity

Description	HDAC-IN-98 is an inhibitor of HDAC1, HDAC2, and HDAC3, with IC₅₀ values of 41.2 nM, 52.5 nM, and 74.3 nM, respectively. HDAC-IN-98 induces H3K9 acetylation, upregulates p21 expression, causes G2/M phase arrest, and induces apoptosis, making it suitable for research on epigenetic regulation in tumors.
Targets&IC50	HDAC2:IC₅₀: 42.6 nM, HDAC3:IC₅₀: 51.8 nM, HDAC1:IC₅₀: 37.2 nM
In vitro	HDAC-IN-98 (1–4 μM; 48 h) disrupts the cell cycle, induces subG1 accumulation leading to apoptosis in HCT116 cells, and causes G1 phase arrest in HT29/DLD1 cells. [1] HDAC-IN-98 (1 μM; in vitro pretreatment; 48 hours) demonstrated potent antitumor activity in a chicken embryo chorioallantoic (CAM) model of colorectal cancer, independent of p21 status. In the HCT116 p21 wild-type CAM model, HDAC-IN-98 was shown to significantly upregulate p21.[1]

Chemical Properties

Molecular Weight	415.44
Formula	C₂₄H₂₁N₃O₄
Smiles	NC1=CC=CC=C1NC(C2=CC=C(CNC(/C=C/C3=CC(OCO4)=C4C=C3)=O)C=C2)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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