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Isonardosinone

Name: Isonardosinone
Brand: TargetMol
SKU: TN4315
Rating: 4.5 (1 reviews)

(Synonyms: (+)-Isonardosinone) Copy Product Info

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Synonyms: (+)-Isonardosinone

Catalog No. TN4315 Copy Product Info

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Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities, inhibits NF-B and MAPK-mediated inflammatory pathways, and attenuates ovx-induced osteoclastogenesis and bone loss.

Cas No. 27062-01-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$678	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$500	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities, inhibits NF-B and MAPK-mediated inflammatory pathways, and attenuates ovx-induced osteoclastogenesis and bone loss.
In vitro	Methods: Isonardosinone (20, 40, 80, 160 μM) was used to treat lipopolysaccharide (LPS)-induced BV2 microglia to investigate its anti-neuroinflammatory effects. Results: Isonardosinone inhibited NF-κB- and MAPK-mediated inflammatory pathways, demonstrating its potential role in the treatment of neuroinflammatory diseases. [1]
Synonyms	(+)-Isonardosinone

Chemical Properties

Molecular Weight	250.33
Formula	C₁₅H₂₂O₃
Cas No.	27062-01-7
Smiles	C[C@@H]1CCC=C2C(=O)[C@H]3O[C@H]3[C@@H](C(C)(C)O)[C@@]12C
Relative Density.	1.15 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc