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Isonardosinone

Name: Isonardosinone
Brand: TargetMol
SKU: TN4315
Rating: 4.5 (1 reviews)

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Catalog No. TN4315Cas No. 27062-01-7

Alias (+)-Isonardosinone

Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities, inhibits NF-B and MAPK-mediated inflammatory pathways, and attenuates ovx-induced osteoclastogenesis and bone loss.

Isonardosinone

😃Good

Catalog No. TN4315Alias (+)-IsonardosinoneCas No. 27062-01-7

Pack Size	Price	Availability	Quantity
10 mg	$678	Backorder
1 mL x 10 mM (in DMSO)	$500	Backorder

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Product Introduction

Bioactivity

Description	Isonardosinone, a nardosinone-type sesquiterpene from Nardostachys jatamansi, exhibits anti-neuroinflammatory and cytotoxic activities, inhibits NF-B and MAPK-mediated inflammatory pathways, and attenuates ovx-induced osteoclastogenesis and bone loss.
In vitro	Methods: Isonardosinone (20, 40, 80, 160 μM) was used to treat lipopolysaccharide (LPS)-induced BV2 microglia to investigate its anti-neuroinflammatory effects. Results: Isonardosinone inhibited NF-κB- and MAPK-mediated inflammatory pathways, demonstrating its potential role in the treatment of neuroinflammatory diseases. [1]
Synonyms	(+)-Isonardosinone

Chemical Properties

Molecular Weight	250.33
Formula	C₁₅H₂₂O₃
Cas No.	27062-01-7
Smiles	C[C@@H]1CCC=C2C(=O)[C@H]3O[C@H]3[C@@H](C(C)(C)O)[C@@]12C
Relative Density.	1.15 g/cm3 (Predicted)

Storage & Solubility Information

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keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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