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CCT251236

Name: CCT251236
Brand: TargetMol
SKU: T14905
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14905Cas No. 1693731-40-6

CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1.

CCT251236

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Purity: 99.89%

Catalog No. T14905Cas No. 1693731-40-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$113	-	In Stock
10 mg	$222	-	In Stock
25 mg	$459	-	In Stock
50 mg	$735	-	In Stock
100 mg	$1,170	-	In Stock
1 mL x 10 mM (in DMSO)	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1.
Targets&IC50	HSP72:19 nM
In vitro	CCT367766 (0-100 nM; 24 hours) inhibited 17-AAG-induced HSF1-mediated expression of heat shock proteins HSP72 and HSP27 in SK-OV-3 cells in a concentration-dependent manner; CCT367766 also blocked 17-AAG-induced HSPA1A mRNA in a dose-dependent manner; in addition, CCT367766 (0-100 nM; 24 hours) exhibited an ideal balance of in vitro properties while maintaining good cell viability, with pIC50=7.73±0.07 (IC50=19 nM) for inhibiting HSF1-mediated HSP72 induction; in SK-OV-3 cells, the free GI50 was 1.1 nM[1].
In vivo	CCT367766 (oral; 20 mg/kg; 33 days) showed significant efficacy in mice, with a tumor growth inhibition (%TGI) of 70% based on final tumor volume.After 33 days, there was a 64% reduction in mean tumor weight compared to controls. In addition, the basicity and high volume of distribution of the compound was observed in tumors up to a concentration of 940 nM [1].CCT367766 (oral, 5 or 20 mg/kg) showed free Cav0-24h values of 2.0 nM and 1.2 nM, respectively, in tumor-free immune-competent BALB/c mice [1]; and, in a mouse model of human myeloma xenografts, the CCT251236 (20 mg/kg, po) inhibited the HSF1 pathway and exhibited antimyeloma efficacy in a human myeloma xenograft mouse model [2].

Chemical Properties

Molecular Weight	552.62
Formula	C₃₂H₃₂N₄O₅
Cas No.	1693731-40-6
Smiles	Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2nc(OCCN3CCCC3)ccc2c1
Relative Density.	1.328 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (144.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8096 mL	9.0478 mL	18.0956 mL	90.4781 mL
5 mM	0.3619 mL	1.8096 mL	3.6191 mL	18.0956 mL
10 mM	0.1810 mL	0.9048 mL	1.8096 mL	9.0478 mL
20 mM	0.0905 mL	0.4524 mL	0.9048 mL	4.5239 mL
50 mM	0.0362 mL	0.1810 mL	0.3619 mL	1.8096 mL
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9048 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc