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TCS 1105

Name: TCS 1105
Brand: TargetMol
SKU: T23444
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23444Cas No. 185391-33-7

Alias N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide

TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice.

TCS 1105

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Purity: 99.75%

Catalog No. T23444Alias N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamideCas No. 185391-33-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$34	-	In Stock
10 mg	$51	-	In Stock
25 mg	$83	-	In Stock
50 mg	$125	-	In Stock
100 mg	$190	-	In Stock
200 mg	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

TCS 1105 AI Summary

TCS 1105 shows bioactivities related to GABA-A central benzodiazepine receptor modulation. It exhibits high inhibition percentages of [3H]-flunitrazepam binding with a Ki value indicating strong affinity, specifically a Ki value of 52.0 nM for [3H]-Ro-15-1788 binding to bovine brain membranes. The compound demonstrates strong displacement of [3H]flumazenil from GABA-A receptors with varying Ki values, including 52.0 nM, 245.0 nM, 118.0 nM, and 163.0 nM for different receptor subunits such as alpha-1-beta-2-gamma-2, alpha-2-beta-2-gamma-2, and alpha-5-beta-3-gamma-2. Additionally, TCS 1105 shows moderate activity in specific binding at the chloride channel site and a GABA ratio close to unity. It also acts as an agonist at GABA-A receptors alpha-1-beta-2-gamma-2 and alpha-2-beta-2-gamma-2 in HEK293 cells, increasing 36Cl- influx by 11.0% and 85.0% respectively. With a relatively high partition coefficient (LogP = 2.88), indicating a propensity for lipophilic interactions, TCS 1105 displays potential anxiolytic and sedative properties through its potent displacer and agonist activities..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand. TCS 1105 blocks Sema3A induced axonal growth cones collapse. TCS 1105 reduces anxiety-like behavior and enhances offensive behavior and social dominance in mice.
Synonyms	N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Chemical Properties

Molecular Weight	296.3
Formula	C₁₇H₁₃FN₂O₂
Cas No.	185391-33-7
Smiles	FC1=CC=C(CNC(=O)C(=O)C2=CNC3=C2C=CC=C3)C=C1
Relative Density.	1.342 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (84.37 mM), Sonication is recommended.

Ethanol: < 5.93 mg/mL, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3750 mL	16.8748 mL	33.7496 mL	168.7479 mL
5 mM	0.6750 mL	3.3750 mL	6.7499 mL	33.7496 mL
10 mM	0.3375 mL	1.6875 mL	3.3750 mL	16.8748 mL
20 mM	0.1687 mL	0.8437 mL	1.6875 mL	8.4374 mL
50 mM	0.0675 mL	0.3375 mL	0.6750 mL	3.3750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc