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DDD01035881 is a novel and highly potent anti-malarial drug that blocks parasite-to-mosquito transmission with nanomolar activity by targeting the Plasmodium vesicle membrane protein Pfs16 and blocking the formation of male gametes in the life cycle of the malaria parasite.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock |
Description | DDD01035881 is a novel and highly potent anti-malarial drug that blocks parasite-to-mosquito transmission with nanomolar activity by targeting the Plasmodium vesicle membrane protein Pfs16 and blocking the formation of male gametes in the life cycle of the malaria parasite. |
In vitro | DDD01035881 (5 μM) selectively blocks Plasmodium falciparum microgametogenesis in a time-dependent manner. Treatment within 5 min after activation disrupts exflagellation and cytoskeletal formation. DNA replication occurs, but structural abnormalities appear[1]. DDD01035881 interferes with Pfs16 function and localization during Plasmodium falciparum microgametogenesis. DDD01035881 blocks proper vesiculation and expulsion of the parasitophorous vacuole membrane (PVM), leading to failed or abnormal egress of gametocytes[1]. |
Alias | DDD 01035881 |
Molecular Weight | 404.3 |
Formula | C14H14BrNO4S2 |
Cas No. | 1396858-56-2 |
Smiles | O=S(=O)(NCC1(O)C=2C=CC=CC2OCC1)C=3SC(Br)=CC3 |
Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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