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LOM612
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Catalog No. T19405Cas No. 2173232-79-4
Alias LOM 612
LOM612 is a potent and specific FOXO relocator that induces nuclear translocation of the FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in a dose-dependent manner in U2OS cells, down-regulates the expression of c-Myc and cyclin D1, and has anti-proliferative effects in human cancer cell lines.
LOM612
😃Good
Catalog No. T19405Alias LOM 612Cas No. 2173232-79-4
LOM612 is a potent and specific FOXO relocator that induces nuclear translocation of the FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in a dose-dependent manner in U2OS cells, down-regulates the expression of c-Myc and cyclin D1, and has anti-proliferative effects in human cancer cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,110 | 6-8 weeks | |
| 50 mg | $1,450 | 6-8 weeks | |
| 100 mg | $2,280 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $318 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LOM612 is a potent and specific FOXO relocator that induces nuclear translocation of the FOXO3a reporter protein as well as endogenous FOXO3a and FOXO1 in a dose-dependent manner in U2OS cells, down-regulates the expression of c-Myc and cyclin D1, and has anti-proliferative effects in human cancer cell lines. |
| Targets&IC50 | FOXO:1.5 μM (EC50) |
| In vitro | LOM612 is cytotoxic to HepG2 cells, with an IC50 value of 0.64 μM, and does not sensitize non-cancer THLE2 cells (IC50, 2.76 μM).LOM612 potently activates nuclear translocation of FOXO with an EC50 value of 1.5 μM, and this effect is independent of CRM-1. LOM612 effectively induces translocation of endogenous FOXO3a and FOXO1, and increases the expression of the FOXO target genes p27 and FasL. LOM612 shows no effect on the nuclear export of endogenous NFKB2 transcription factor in U2OS cells. [1] |
| In vivo | LOM612 suppressed tumor growth in MCF-7 cell-derived xenograft mouse models by promoting FOXO1 nuclear localization, downregulating c-Myc and cyclin D1 expression, and showed enhanced antitumor efficacy when combined with selinexor.[2] |
| Alias | LOM 612 |
| Molecular Weight | 258.3 |
| Formula | C13H10N2O2S |
| Cas No. | 2173232-79-4 |
| Smiles | O=C1C=2SN=C(C2C(=O)C=3C=CC=CC13)N(C)C |
| Relative Density. | 1.436 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: < 1 mg/mL (insoluble), Sonication is recommended. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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