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Zifaxaban

🥰Excellent
Catalog No. T29215Cas No. 1378266-98-8
Alias TY-602, TY602, TY 602

Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other serine proteases.Zifaxaban can be used to study arterial and venous thrombosis.

Zifaxaban

Zifaxaban

🥰Excellent
Purity: 99.82%
Catalog No. T29215Alias TY-602, TY602, TY 602Cas No. 1378266-98-8
Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other serine proteases.Zifaxaban can be used to study arterial and venous thrombosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$350In StockIn Stock
5 mg$828In StockIn Stock
10 mg$1,130In StockIn Stock
25 mg$1,590In StockIn Stock
50 mg$1,980In StockIn Stock
100 mg$2,500In StockIn Stock
500 mg$4,900-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.82%
ee:100%
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COA CSFC HNMR ORP HPLC

Product Introduction

Bioactivity
Description
Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other serine proteases.Zifaxaban can be used to study arterial and venous thrombosis.
Targets&IC50
FXa (human):11.1 nM
In vivo
Zifaxaban (rat venous thrombosis model) strongly inhibits thrombosis with an ED50 value of 3.09 mg/kg, with optimal efficacy occurring 2 hours after administration.[1]
Zifaxaban inhibits thrombosis in a dose-dependent manner in rat arteriovenous shunt thrombosis and carotid artery thrombosis models.[1]
SynonymsTY-602, TY602, TY 602
Chemical Properties
Molecular Weight429.88
FormulaC20H16ClN3O4S
Cas No.1378266-98-8
SmilesO=C1N(C[C@H](CNC(=O)C=2SC(Cl)=CC2)O1)C3=CC=C(C=C3)N4C(=O)C=CC=C4
Relative Density.1.461 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (139.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3262 mL11.6312 mL23.2623 mL116.3115 mL
5 mM0.4652 mL2.3262 mL4.6525 mL23.2623 mL
10 mM0.2326 mL1.1631 mL2.3262 mL11.6312 mL
20 mM0.1163 mL0.5816 mL1.1631 mL5.8156 mL
50 mM0.0465 mL0.2326 mL0.4652 mL2.3262 mL
100 mM0.0233 mL0.1163 mL0.2326 mL1.1631 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

ZifaxabanFactorXaFactor Xa
Related Tags: buy Zifaxaban | purchase Zifaxaban | Zifaxaban cost | order Zifaxaban | Zifaxaban chemical structure | Zifaxaban in vivo | Zifaxaban formula | Zifaxaban molecular weight
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