4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc)

Name: 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc)
Brand: TargetMol
SKU: TMPS-00001
Rating: 4.5 (1 reviews)

(Synonyms: TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB) Copy Product Info

Synonyms: TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB

Catalog No. TMPS-00001 Copy Product Info

4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q07011.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$66	7-10 days	7-10 days
10 µg	$106	7-10 days	7-10 days
20 µg	$173	7-10 days	7-10 days
50 µg	$339	7-10 days	7-10 days
100 µg	$573	7-10 days	7-10 days
200 µg	$977	7-10 days	7-10 days
500 µg	$1,980	7-10 days	7-10 days
1 mg	$3,390	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a ligand-receptor binding ELISA. When recombinant 4-1BB/CD137/TNFRSF9, hFc, Human is Immobilized at 1.0 µg/ml (100 µl/well), the concentration of recombinant human 4-1BB Ligand that produces 50% optimal binding response is found to be approximately 5.0-15.0 ng/ml.
Description	4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is Q07011.
Species	Human
Expression System	CHO Cells
Tag	hFc
Accession Number	Q07011
Construction	Leu24-Gln186
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	TNFRSF9, T-cell antigen ILA, CD137 antigen, 4-1BB
Research Background	4-1BB(CD137) is a member of the tumor necrosis factor (TNF) receptor family. Mature human 4-1BB consists of a 163 amino acid extracellular domain (ECD) with four TNFR cysteine‑rich repeats, a 27 aa transmembrane segment, and a 42 aa cytoplasmic domain; 4-1BB (CD137) is expressed as a disulfide-linked homodimer on various populations of activated T cell including CD4 + , CD8 + , memory CD8 + , NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells. This interaction co stimulates the proliferation, activation, and/or survival of the 4-1BB expressing cell. It can also enhance the activation-induced cell death of repetitively stimulated T cells.

Chemical Properties

Molecular Weight

55~60 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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Related Tags: 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) chemical structure | 4-1BB/CD137/TNFRSF9 Protein, Human, Recombinant (CHO, hFc) molecular weight