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h-NTPDase-IN-4

Name: h-NTPDase-IN-4
Brand: TargetMol
SKU: T77661
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77661Cas No. 2939933-09-0

h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM and 13.57 μM, respectively.

h-NTPDase-IN-4

🥰Excellent

Purity: 99.92%

Catalog No. T77661Cas No. 2939933-09-0

h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM and 13.57 μM, respectively.

Pack Size	Price	Availability
1 mg	$61	In Stock
5 mg	$147	In Stock
10 mg	$236	In Stock
25 mg	$473	In Stock
50 mg	$757	In Stock
100 mg	$987	In Stock

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Batch Information

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Purity:99.92%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	h-NTPDase-IN-4 is a pan-inhibitor of NTPDase, which can inhibit h-NTPDase1, 1h-NTPDase2, h-NTPDase3, h-NTPDase8. The IC50 values were 3.58 μM, 10.21 μM, 0.13 μM and 13.57 μM, respectively.
Targets&IC50	NTPDase1 (human):3.58 μM, NTPDase8 (human):13.57 μM, NTPDase3 (human):0.13 μM, NTPDase2 (human):10.21 μM

Chemical Properties

Molecular Weight	560.36
Formula	C₂₂H₈F₁₂N₂S
Cas No.	2939933-09-0
Smiles	C(F)(F)(F)C=1C=C(C2=C3C(C(=CS3)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=NC=N2)C=C(C(F)(F)F)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 56.04 mg/mL (100 mM), Sonication is recommended.

Solution Preparation Table

DMF

	1mg	5mg	10mg	50mg
1 mM	1.7846 mL	8.9228 mL	17.8457 mL	89.2284 mL
5 mM	0.3569 mL	1.7846 mL	3.5691 mL	17.8457 mL
10 mM	0.1785 mL	0.8923 mL	1.7846 mL	8.9228 mL
20 mM	0.0892 mL	0.4461 mL	0.8923 mL	4.4614 mL
50 mM	0.0357 mL	0.1785 mL	0.3569 mL	1.7846 mL
100 mM	0.0178 mL	0.0892 mL	0.1785 mL	0.8923 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc