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rel-(2R,3R)-Nitric oxide production-IN-11k (Synonyms: rel-(2S,3S)-Nitric oxide production-IN-11k)
Catalog No. TN9824 Copy Product Info
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rel-(2R,3R)-Nitric oxide production-IN-11k is an isomer of Nitric oxide production-IN-11k (T206206). Nitric oxide production-IN-11k is a compound that exerts anti-inflammatory effects by inhibiting the TLR4, JNK, and NF-κB signaling pathways. Nitric oxide production-IN-11k suppresses nitric oxide (NO) production in LPS-stimulated RAW264.7 cells, with an IC₅₀ of 23.2 µM. The mechanism of action involves downregulation of TLR4 expression, inhibition of JNK phosphorylation, and suppression of NF-κB activation, thereby reducing the expression of iNOS and COX-2 and consequently decreasing the production of inflammatory mediators such as NO, PGE₂, and TNF-α.
rel-(2R,3R)-Nitric oxide production-IN-11k
Copy Product Info😃Good
Catalog No. TN9824
Synonyms rel-(2S,3S)-Nitric oxide production-IN-11k
rel-(2R,3R)-Nitric oxide production-IN-11k is an isomer of Nitric oxide production-IN-11k (T206206). Nitric oxide production-IN-11k is a compound that exerts anti-inflammatory effects by inhibiting the TLR4, JNK, and NF-κB signaling pathways. Nitric oxide production-IN-11k suppresses nitric oxide (NO) production in LPS-stimulated RAW264.7 cells, with an IC₅₀ of 23.2 µM. The mechanism of action involves downregulation of TLR4 expression, inhibition of JNK phosphorylation, and suppression of NF-κB activation, thereby reducing the expression of iNOS and COX-2 and consequently decreasing the production of inflammatory mediators such as NO, PGE₂, and TNF-α.
Cas No. 1010705-14-2
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| Description | rel-(2R,3R)-Nitric oxide production-IN-11k is an isomer of Nitric oxide production-IN-11k (T206206). Nitric oxide production-IN-11k is a compound that exerts anti-inflammatory effects by inhibiting the TLR4, JNK, and NF-κB signaling pathways. Nitric oxide production-IN-11k suppresses nitric oxide (NO) production in LPS-stimulated RAW264.7 cells, with an IC₅₀ of 23.2 µM. The mechanism of action involves downregulation of TLR4 expression, inhibition of JNK phosphorylation, and suppression of NF-κB activation, thereby reducing the expression of iNOS and COX-2 and consequently decreasing the production of inflammatory mediators such as NO, PGE₂, and TNF-α. |
| Synonyms | rel-(2S,3S)-Nitric oxide production-IN-11k |
| Molecular Weight | 344.4 |
| Formula | C23H20O3 |
| Cas No. | 1010705-14-2 |
| Smiles | O=C1[C@@H]([C@H](C=2C1=CC=C(OC)C2)C3=CC=CC=C3)C4=CC=C(OC)C=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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