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Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187)
🥰Excellent
Catalog No. TMAY-03153
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) is a Rabbit antibody targeting Alpha 2 Antiplasmin/SerpinF2. Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) can be used in ELISA,ELISA(Cap),IHC-P.
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187)
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187)
🥰Excellent
Catalog No. TMAY-03153
Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) is a Rabbit antibody targeting Alpha 2 Antiplasmin/SerpinF2. Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) can be used in ELISA,ELISA(Cap),IHC-P.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) is a Rabbit antibody targeting Alpha 2 Antiplasmin/SerpinF2. Anti-Alpha 2 Antiplasmin/SerpinF2 Antibody (4P187) can be used in ELISA,ELISA(Cap),IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4P187 |
| Reactivity | Mouse |
| Verified Activity | Immunochemical staining of mouse SERPINF2 in mouse liver with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections). |
| Application | ELISA,ELISA(Cap),IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:50-1:200; ELISA(Cap): 1:250-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SerpinF2 (rM SerpinF2; TMPY-01026; NP_032904.1; Met 1-Lys 491). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta at a moderate level. It is indicated that Serpin F2 is a key regulator of plasmin-mediated proteolysis in these tissues. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. SerpinF2 is one of the inhibitors of fibrinolysis, which acts as the primary inhibitor of plasmin(ogen). It is a specific plasmin inhibitor, and is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the congenital deficiency of Alpha-2 antiplasmin causes a rare bleeding disorder because of increased fibrinolysis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse SerpinF2 protein (TMPY-01026) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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