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AUNP-12 acetate

Name: AUNP-12 acetate
Brand: TargetMol
SKU: TP1076L
Price: 116 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1076L

Alias AUNP-12 acetate (1353563-85-5 Free base)

AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.

AUNP-12 acetate

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Purity: 95.07%

Catalog No. TP1076LAlias AUNP-12 acetate (1353563-85-5 Free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$116	In Stock	In Stock
5 mg	$326	In Stock	In Stock
10 mg	$489	-	In Stock
25 mg	$798	-	In Stock
50 mg	$1,090	Inquiry	Inquiry
100 mg	$1,480	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.07%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	AUNP-12 acetate is a polypeptide inhibitor of PD-1 that is equivalent to PD-1 and PD-2 in inhibiting lymphocyte proliferation and effector fuction, in addition to immune activation and antitumor activity.
In vitro	In vitro, AUNP-12 displayed equipotent antagonism toward PD-L1 and PD-L2 in the rescue of lymphocyte proliferation and effector functions. In human PBMC cells, AUNP-12 was also able to significantly rescue recombinant human PD-L1 and PD-L2 mediated inhibition in vitro, with average EC50 values of 63.3 nM and 44.1 nM against PD-L1 and PD-L2 respectively. [1]
In vivo	AUNP-12 acetate rescued the proliferation in the mouse splenocyte assay system, with average EC50 values of 17 nM and 16.6 nM against rmPD-L1 and rmPD-L2 respectively. AUNP-12 (6 hours) showed a Plasma protein binding of 93.9% with plasma stability of more than 60%. AUNP-12 exhibited a half-life of 90 minutes in mouse liver microsomes. In male Balb/c mice, AUNP-12 subcutaneous injection or intravenous injection as a concentration of 3 mg/kg for its PK study. As a result, AUNP-12 shows a low volume of distribution, and the peak plasma levels reach at 0.2-0.4 hours. The absolute bioavailability of AUNP-12 is about 77% in mice. [1]
Synonyms	AUNP-12 acetate (1353563-85-5 Free base)

Chemical Properties

Molecular Weight	3321.61
Formula	C₁₄₄H₂₃₀N₄₀O₅₀
Smiles	O=C([C@@](NC([C@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NN)(CCC(O)=O)[H])=O)(CCCCN)[H])=O)([C@@](CC)(C)[H])[H])=O)(CCC(N)=O)[H])=O)(C)[H])=O)(CCCCN)[H])N1[C@@](CCC1)(C(N[C@@](C(C([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC(C(CCCCNN[C@@](CC2=CC=CC=C2)(C(N([H])[C@](C(N[C@@](C(CC(O)=O)([H])[H])(C(N[C@](C(N[C@@]([C@@](O)(C)[H])(C(N[C@@](CC(N)=O)(C(N[C@@](CO)(C([H])=O)[H])=O)[H])=O)[H])=O)(CO)[H])=O)[H])=O)(CO)[H])=O)[H])NC([C@@](N([H])C([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](NC([C@@](N)(CO)[H])=O)(CC(N)=O)[H])=O)([C@@](O)(C)[H])[H])=O)(CO)[H])=O)(CCC(O)=O)[H])=O)(CO)[H])=O)(CC3=CC=CC=C3)[H])=O)=O)(CC4=CC=CC=C4)[H])=O)(CCCNC(N)=N)[H])=O)(C(C)(C)[H])[H])=O)([C@@](O)(C)[H])[H])=O)(CCC(N)=O)[H])=O)(CC(C)C)[H])=O)=O)(C)[H])=O)[H].CC(O)=O
Sequence	Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(1)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2.H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-(1)
Sequence Short	SNTSESFKF(H-SNTSESF)RVTQLAPKAQIKE

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (30.11 mM), Sonication is recommended.

H2O: 25 mg/mL (7.53 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.3011 mL	1.5053 mL	3.0106 mL	15.0529 mL
5 mM	0.0602 mL	0.3011 mL	0.6021 mL	3.0106 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.0301 mL	0.1505 mL	0.3011 mL	1.5053 mL
20 mM	0.0151 mL	0.0753 mL	0.1505 mL	0.7526 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc