TGFBR2 Protein, Human, Recombinant (His)

Name: TGFBR2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-05157
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: transforming growth factor, β receptor II, transforming growth factor, beta receptor II (70/80kDa), TGFβ-RII, TGFR-2, TGFbeta-RII, TAAD2, RIIC, MFS2, LDS2B, LDS2, LDS1B, FAA3, AAT3) Copy Product Info

Synonyms: transforming growth factor, β receptor II, transforming growth factor, beta receptor II (70/80kDa), TGFβ-RII, TGFR-2, TGFbeta-RII, TAAD2, RIIC, MFS2, LDS2B, LDS2, LDS1B, FAA3, AAT3

Catalog No. TMPY-05157 Copy Product Info

TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.

Pack Size	Price	USA Stock	Global Stock
5 µg	$41	-	In Stock
10 µg	$63	-	In Stock
20 µg	$100	7-10 days	7-10 days
50 µg	$192	7-10 days	7-10 days
100 µg	$320	-	In Stock
200 µg	$615	7-10 days	7-10 days
500 µg	$1,490	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:89.3%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 μg/mL (100 μL/well) can bind TGFB1-His/Biotin , the EC50 of human TGFB1-His/Biotin is 130-300 ng/mL.
Description	TGFBR2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P37173.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	C-His
Accession Number	P37173
Construction	A DNA sequence encoding the human TGFBR2 (NP_003233.4) (Met1-Gln166) was expressed with a polyhistidine tag at the C-terminus. Predicted N terminal: Thr 23
Protein Purity	> 90 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PBS, 150 mM NaCl, 10% glycerol, 0.5 mM TCEP, pH 7.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	transforming growth factor, β receptor II, transforming growth factor, beta receptor II (70/80kDa), TGFβ-RII, TGFR-2, TGFbeta-RII, TAAD2, RIIC, MFS2, LDS2B, LDS2, LDS1B, FAA3, AAT3
Research Background	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.

Chemical Properties

Molecular Weight

17.8 kDa (predicted); 24 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.