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Anti-MMP-1 Antibody (2Y884)

😃Good
Catalog No. TMAY-00955
Alias matrix metallopeptidase 1, CLGN, CLG

Anti-MMP-1 Antibody (2Y884) is a Mouse antibody targeting MMP-1. Anti-MMP-1 Antibody (2Y884) can be used in ELISA.

Anti-MMP-1 Antibody (2Y884)

Anti-MMP-1 Antibody (2Y884)

😃Good
Catalog No. TMAY-00955Alias matrix metallopeptidase 1, CLGN, CLG
Anti-MMP-1 Antibody (2Y884) is a Mouse antibody targeting MMP-1. Anti-MMP-1 Antibody (2Y884) can be used in ELISA.
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20 μL$70 7-10 days
100 μL$198 7-10 days
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Product Introduction

Bioactivity
Description
Anti-MMP-1 Antibody (2Y884) is a Mouse antibody targeting MMP-1. Anti-MMP-1 Antibody (2Y884) can be used in ELISA.
Aliasmatrix metallopeptidase 1, CLGN, CLG
Ig Type
Monoclonal Mouse IgG1
Clone
2Y884
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MMP1 (rh MMP1; TMPY-00886; NP_002412.1; Met1-Asn469). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundMMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defenses. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Tumour metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondary at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human MMP1 Protein (TMPY-00886)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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