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Ritanserin

Name: Ritanserin
Brand: TargetMol
SKU: T16759
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16759Cas No. 87051-43-2

Alias R 55667

Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM.

Ritanserin

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Purity: 99.89%

Catalog No. T16759Alias R 55667Cas No. 87051-43-2

Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM.

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$77	In Stock
25 mg	$155	In Stock
50 mg	$246	In Stock
100 mg	$395	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock

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Purity:99.89%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Ritanserin (R 55667) is a long-acting, highly potent, relatively selective, orally bioavailable 5-HT2 receptor antagonist with an IC50 of 0.9 nM.
Targets&IC50	α2-adrenoceptor:150 nM, H1:35 nM, α1-adrenoceptor:97 nM, 5-HT2:0.9 nM, D2:70 nM
In vitro	METHODS: AML cell lines Kasumi-1 and KG-1α were treated with Ritanserin (R 55667) (10, 20, 30, 40, 50, 60 μM), and cytotoxicity was determined by CCK-8. RESULTSRitanserin (R 55667) significantly reduced the proliferation activity of AML cells in a dose-dependent and time-dependent manner. [1] Ritanserin (R 55667) has low activity against multiple receptors, including histamine-H1 (IC50, 35 nM), dopamine-D2 (IC50, 70 nM), adrenergic-α1 (IC50, 97 nM), and adrenergic-α2 receptors (IC50, 150 nM).[2]
Synonyms	R 55667

Chemical Properties

Molecular Weight	477.57
Formula	C₂₇H₂₅F₂N₃OS
Cas No.	87051-43-2
Smiles	Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1
Relative Density.	1.3g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (104.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0939 mL	10.4697 mL	20.9393 mL	104.6967 mL
5 mM	0.4188 mL	2.0939 mL	4.1879 mL	20.9393 mL
10 mM	0.2094 mL	1.0470 mL	2.0939 mL	10.4697 mL
20 mM	0.1047 mL	0.5235 mL	1.0470 mL	5.2348 mL
50 mM	0.0419 mL	0.2094 mL	0.4188 mL	2.0939 mL
100 mM	0.0209 mL	0.1047 mL	0.2094 mL	1.0470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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