Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

SNIPERs

SNIPERs are a class of small molecule degraders that induce IAP-mediated ubiquitination and proteasomal degradation of target proteins by recruiting RING E3 ubiquitin ligases of IAP family.

SNIPER(TACC3)-2 hydrochloride
T81141
SNIPER(TACC3)-2 hydrochloride is a compound that induces degradation of the TACC3 protein through the ubiquitin-proteasome pathway by exploiting an IAP ligand, leading to the induction of cancer cell death [1].
  • Inquiry Price
Size
QTY
SNIPER(ABL)-015
T18685
SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5 μM [1].
  • Inquiry Price
Size
QTY
PROTAC AR Degrader-4
T185961351169-31-7
PROTAC AR Degrader-4 comprises a cIAP1 ligand binding group, a linker, and an androgen receptor (AR) binding group. It is an AR degrader and is considered a specific and non-genetic IAP-dependent protein eraser (SNIPER) [1].
    Inquiry
    PROTAC AR Degrader-4 TFA
    T73726
    PROTAC AR Degrader-4, an Androgen Receptor (AR) degrader, incorporates an IAP ligand binding group, a linker, and an AR binding group. It represents a class of degradation inducers known as specific and non-genetic IAP-dependent protein erasers (SNIPERs) [1], operating through a mechanism involving cIAP1.
    • Inquiry Price
    Size
    QTY
    PROTAC CRABP-II Degrader-2
    T138371225383-38-9
    PROTAC CRABP-II Degrader-2 is a potent cIAp1-based degrader of cellular retinoic acid binding protein (CRABP-II).
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-024
    T186882222355-77-1
    SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 5μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-033
    T186892222354-18-7
    SNIPER(ABL)-033, a compound that conjugates HG-7-85-01 (ABL inhibitor) to a LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-050
    T18694
    SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-019
    T18686
    SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ER)-110
    T18696
    SNIPER(ER)-110 comprises a cIAP1 ligand and an estrogen ligand connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively [1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-039
    T186902222354-29-0
    SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to an LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM for ABL, 10 nM for cIAP1, 12 nM for cIAP2, and 50 nM for XIAP[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-013
    T18684
    SNIPER(ABL)-013, a compound that links GNF5 (ABL inhibitor) with Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 20 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-058
    T186952222354-61-0
    SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of 10 μM[1].
    • Inquiry Price
    Size
    QTY
    PROTAC ERα Degrader-2
    T186051351169-29-3
    PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-047
    T18692
    SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(TACC3)-11
    T744622906151-68-4
    SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, significantly reducing its levels and inhibiting the proliferation of FGFR3-TACC3-positive cancer cells [1].
    • Inquiry Price
    8-10 weeks
    Size
    QTY
    SNIPER(TACC3)-1 hydrochloride
    T81142
    SNIPERTACC3-1 hydrochloride, an IAP ligand-based compound, selectively degrades the TACC3 protein through the ubiquitin-proteasome pathway, thereby inducing cancer cell apoptosis [1].
    • Inquiry Price
    Size
    QTY
    SNIPER(TACC3)-1
    T13891
    SNIPER(TACC3)-1 targets TACC3 protein degradation via the ubiquitin-proteasome pathway.It induces cancer cell death.
    • Inquiry Price
    Size
    QTY
    SNIPER(TACC3)-2
    T13892
    SNIPER(TACC3)-2 targets TACC3 protein degradation via the ubiquitin-proteasome pathway. It induces cancer cell death.
    • Inquiry Price
    Size
    QTY
    BzNH-BS
    T17706
    BzNH-BS is a chemical compound comprising two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide. The ligands are interconnected through linkers. MeBS functions as a ligand for cIAP1, a ubiquitin ligase involved in cellular inhibition of apoptosis processes [1].
    • Inquiry Price
    Size
    QTY
    PROTAC RAR Degrader-1
    T186351351169-27-1
    PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation inducers that utilize cIAP1 are known as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-044
    T18691
    SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a DC50 value of 10 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(ABL)-049
    T18693
    SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels, demonstrating a DC50 of 100 μM[1].
    • Inquiry Price
    Size
    QTY
    SNIPER(BRD)-1
    T169052095244-54-3
    SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway and effectively degrades cIAP1, cIAP2, and XIAP with IC50 values of 6.8 nM, 17 nM, and 49nM, respectively[1].
    • Inquiry Price
    Size
    QTY