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D-α-Tocopherol acetate

Name: D-α-Tocopherol acetate
Brand: TargetMol
SKU: T1016
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1016Cas No. 58-95-7

Alias Vitamin E Acetate, Tocopherol acetate

D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.

D-α-Tocopherol acetate

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Purity: 98.84%

Catalog No. T1016Alias Vitamin E Acetate, Tocopherol acetateCas No. 58-95-7

D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.84%

Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS HNMR HPLC

Product Introduction

D-α-Tocopherol acetate AI Summary

D-α-Tocopherol acetate has been evaluated for various bioactivities across multiple assays. It was tested for antiproliferative activity against the human breast cancer cell line MCF-7 using the MTT assay and demonstrated an IC50 value greater than 500,000 nM, indicating limited effectiveness in this context. Additionally, it inhibits GCN5L2, induces DNA re-replication in colon adenocarcinoma cells, and blocks Ebola virus entry through multiple mechanisms, showing potency in the nanomolar to micromolar range. D-α-Tocopherol acetate also protects against IL1-beta-induced cell damage in NHEK cells by inhibiting PGE2 production at concentrations of 0.1 µM, 0.5 µM, and 2 µM, with respective inhibitions of 38.0%, 40.0%, and 67.0%. It further shows a protective effect against t-BHP-induced cell damage with 77.4% inhibition and against H2O2-induced cell damage with 25.0% inhibition at 2 µM after 24 hours. In mouse N18TG2 cells, the compound undergoes complete degradation, leading to 100.0% alpha-TOH formation after 24 hours. Moreover, it weakly inhibits the bovine mitochondrial electron transport protein complex 2 succinate: DCPIP oxidoreductase activity with an IC50 value higher than 1,000,000 nM. D-α-Tocopherol acetate also acts as a SARS-CoV-2 3CL-Pro protease inhibitor, showing 30.78% inhibition at 20 µM. Despite this, it exhibits minimal antiviral activity against SARS-CoV-2 with a 0.17% inhibition rate in VERO-6 cells at 10 µM after 48 hours. While demonstrating moderate inhibitory activity against PDE3A and PDE4A with AC50 values of 932.7 nM and 9,379.5 nM, respectively, its binding affinity and bioactivity concerning various receptors and enzymes generally remain low, with AC50 values exceeding 30,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-alpha-Tocopherol acetate (Vitamin E Acetate) is hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
Synonyms	Vitamin E Acetate, Tocopherol acetate

Chemical Properties

Molecular Weight	472.74
Formula	C₃₁H₅₂O₃
Cas No.	58-95-7
Smiles	CC1=C2C(=C(C)C(OC(C)=O)=C1C)CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2
Relative Density.	0.953 g/mL at 25°C(lit.)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (528.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1153 mL	10.5766 mL	21.1533 mL	105.7664 mL
5 mM	0.4231 mL	2.1153 mL	4.2307 mL	21.1533 mL
10 mM	0.2115 mL	1.0577 mL	2.1153 mL	10.5766 mL
20 mM	0.1058 mL	0.5288 mL	1.0577 mL	5.2883 mL
50 mM	0.0423 mL	0.2115 mL	0.4231 mL	2.1153 mL
100 mM	0.0212 mL	0.1058 mL	0.2115 mL	1.0577 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc