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Simmiparib

Name: Simmiparib
Brand: TargetMol
SKU: T63228
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63228Cas No. 1551355-46-4

Alias SMOCL-9112

Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.

Simmiparib

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Purity: 99.51%

Catalog No. T63228Alias SMOCL-9112Cas No. 1551355-46-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$479	In Stock	In Stock
25 mg	$892	In Stock	In Stock
50 mg	$1,380	In Stock	In Stock
100 mg	$2,220	-	In Stock
200 mg	$2,990	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.51%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.
Targets&IC50	PARP1:0.74 nM, PARP2:0.22 nM
In vitro	Simmiparib, when applied at concentrations ranging from 0 to 10 μM for 3 days, demonstrates anti-proliferative activity against various cancer cells[1]. In Capan-1 cells, Simmiparib induces typical G2/M arrest when administered at concentrations of 0-10 μM for 48 hours[1]. Apoptosis is induced in MDA-MB-436 and V-C8 (BRCA2-/-) cells by Simmiparib at concentrations of 0.1-2 μM for 24 hours. Additionally, there is a dose-dependent increase in the levels of γH2AX[1].Furthermore, treatment with Simmiparib at concentrations of 1-10 μM for 48 or 72 hours increases the phosphorylation levels of Chk1 and Chk2. Additionally, it enhances the protein levels of p-Cyclin B1 (S147), Cyclin B1, p-CDK1 (Y15), and CDK1[1].
In vivo	In xenograft mouse models, Simmiparib inhibits the growth of tumors in V-C8 (BRCA2-/-) and MDA-MB-436 (BRCA2-/-) when administered orally at doses of 2, 4, and 8 mg/kg once daily for 14 days[1].Additionally, Simmiparib, at doses of 10 and 50 mg/kg administered orally once daily for 42 days, inhibits the growth of BRCA1-mutated breast cancer in xenograft mouse models[1].
Synonyms	SMOCL-9112

Chemical Properties

Molecular Weight	486.42
Formula	C₂₃H₁₈F₄N₆O₂
Cas No.	1551355-46-4
Smiles	CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (164.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0558 mL	10.2792 mL	20.5584 mL	102.7918 mL
5 mM	0.4112 mL	2.0558 mL	4.1117 mL	20.5584 mL
10 mM	0.2056 mL	1.0279 mL	2.0558 mL	10.2792 mL
20 mM	0.1028 mL	0.5140 mL	1.0279 mL	5.1396 mL
50 mM	0.0411 mL	0.2056 mL	0.4112 mL	2.0558 mL
100 mM	0.0206 mL	0.1028 mL	0.2056 mL	1.0279 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc